Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Orthopaedic Surgery
  •  Transplant Surgery
  •  Emergency Surgery
  •  Urology
  •  General Surgery
  •  Gynecological Surgery
  •  Neurological Surgery
  •  Thoracic Surgery


Citation: Clin Surg. 2018;3(1):2139.Research Article | Open Access

Unenhanced Chest CT Assisted SLNB could be a Highly Reliable Option for only Methylene Blue available Breast Cancer Patients

Haiyan Wei, Minya Yao, Peifen Fu and Xiaoqun Ba

Department of Breast, Zhejiang University School of Medicine, China
Department of Pathology, Zhejiang University School of Medicine, China

*Correspondance to: Haiyan Wei 

 PDF  Full Text DOI: 10.25107/2474-1647.2139


Background: Blue dye and Radioisotope (RI) combined SLNB is the “best” protocol. However, RI is not available worldwide. This study is to evaluate the feasibility of unenhanced chest Computerized Tomography (CT) with three criteria for suspicious nodal metastasis assisted SLNB using only Methylene Blue (MB) as an alternative reliable option.Patients and
Methods: A total of 1771 consecutive patients with clinically node negative breast cancer were enrolled. For limiting FNR and surgical complications, the number of removed Sentinel Lymph Nodes (SLNs) was suggested to be 3~5. Unenhanced chest CT is mandatory to locate SLNs, which were graded from 1 to 3 according to suspicious criteria for metastasis. Three doctors adopted three SLNB methods. Periareolar sub-dermal injection using 4 ml of 0.5% MB, alone or in combination with a radioisotope was individually employed by two doctors. The third doctor used 2 ml of 1% MB to inject into parenchyma to map SLNs.Results: Both FNR and outcomes of patients showed no difference between three methods. We also confirmed that Lymphovascular Invasion (LVI) and CT grade were both significantly correlated with SLN status (coefficients were 0.68 and 0.25, p<0.001). Although there was no difference found in complications, but parenchymal injection did never cause skin necrosis.Conclusion: Unenhanced chest CT could be are liable assistance to improve SLNB using only MB via parenchymal injection. This technique might be the safest and convenient option for SLNB in the study and RI could be safely spared.


Breast cancer; Sentinel lymph node biopsy; Methylene blue; Computerized tomography

Cite the article

Wei H, Yao M, Fu P, Ba X. Unenhanced Chest CT Assisted SLNB could be a Highly Reliable Option for only Methylene Blue available Breast Cancer Patients. Clin Surg. 2018; 3: 2139.

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