LODDS was a Better Predictor for Lymph Node Status and was a Dependent Poor Prognostic Factor for Distal Extrahepatic Cholangiocarcinoma after Radical Surgical Resection

Wenqin Wang, Xiang Chen and Xiaodong He

Department of General Surgery, Peking Union Medical College, China
Department of Food and Drug Administration, Wei Fang College Hospital, China

^*Correspondance to: Xiaodong He 

 PDF  Full Text DOI: 10.25107/2474-1647.2446

Abstract

Background: Whether log of odds between the number of positive lymph node and the Number of Negative Lymph Node (LODDS) predict lymph node status and oncological outcomes for Distal Extrahepatic Cholangiocarcinoma (dECA) patients after curative resection remains rarely studied.
Methods: A 743 patients from SEER database between 2004 and 2014 who received curative Pancreatoduodenectomy (PD) were analyzed. We conducted Receiver Operating Characteristic (ROC) curve and univariate (Log-Rank) and multivariate (Cox regression) analysis to identify the diagnostic and prognostic roles of LODDS.
Results: LODDS was the effective variable with the area under the ROC curve (AUC) for prediction of 3-year survival (AUC=0.593) to predict the survival, we determined the optimum cut-off value of LODDS and LODDS<-0.94. In multivariate analysis, LODDS (Hazard Ratio (HR)=0.738, 95% CI 0.574-0.949, P=0.018) was independent prognostic factor for OS.
Conclusion: LODDS was proved to be a good indicator predict for lymph node and survival as an independent indictor for OS in dECA after radical surgical resection.

Keywords

LODDS; Disease free survival; Distal extrahepatic carcinoma; Pancreatoduodenectomy

Cite the article

Wang W, Chen X, He X. LODDS was a Better Predictor for Lymph Node Status and was a Dependent Poor Prognostic Factor for Distal Extrahepatic Cholangiocarcinoma after Radical Surgical Resection. Clin Surg. 2019; 4: 2446.