Impact of Roux-en-Y Gastric Bypass on Bone Metabolism in Chinese Obese Patient

Yanling Cai#, Tsz Hong Chong#, Juzheng Peng#, Tsz Kin Mak#, Jingge Yang* and Lilian Gao*

Department of International Bariatric Center, First Affiliated Hospital of Jinan University, Guangzhou, China
#These authors contributed equally to this work

^*Correspondance to: Jingge Yang 

 PDF  Full Text DOI: 10.25107/2474-1647.2802

Abstract

Introduction: Changes in bone metabolism following Roux-en-Y Gastric Bypass (RYGB) in obese patients have yielded inconsistent results. Nevertheless, no data exist on changes in Calcium (Ca) metabolism after RYGB in Chinese obese subjects. Objectives: The aim of this study was to identify the impact of RYGB on vitamin D, Parathyroid Hormone (PTH), Ca and Phosphorus (P) metabolism in Chinese obese patients, and predictors of postoperative change. Methods: The patient undergoing RYGB between January 2015 and October 2018 in our hospital was retrospectively reviewed. Serum PTH, P, Ca, and 25-hydroxyvitamin D (25OHD) levels were collected before and 6 months after RYGB. Result: In total, 165 patients were included in the study. After RYGB, the mean Body Mass Index (BMI) level significantly reduced, the Ca, P and 25OHD levels increased, while the PTH level remained similar. Preoperative PTH level, percentage of Excess Weight Loss (%EWL), and BMI change were independent predictors of postoperative PTH change. Preoperative P and Ca levels could predict postoperative P and Ca change, respectively. Conclusion: A significant increase in serum 25OHD, Ca, and P are expected after RYGB at the short term. And preoperative 25OHDand Ca levels are predictors of postoperative change.

Keywords

Roux-en-Y Gastric Bypass (RYGB); Vitamin D; Parathyroid Hormone (PTH); Ca-P Metabolism; Obesity

Cite the article

Cai Y, Hong TC, Peng J, Kin Mak T, Yang J, Gao L. Impact of Roux-en-Y Gastric Bypass on Bone Metabolism in Chinese Obese Patient. Clin Surg. 2020; 5: 2802..