Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Robotic Surgery
  •  Colon and Rectal Surgery
  •  Vascular Surgery
  •  Obstetrics Surgery
  •  Endocrine Surgery
  •  Neurological Surgery
  •  Ophthalmic Surgery
  •  Orthopaedic Surgery


Citation: Clin Surg. 2020;5(1):2819.Review Article | Open Access

PDGF/PDGFR Signaling in Cardiovascular Disease

Jing Wang, Dongcheng Cai, Hongxia Liu, Yuanyuan Tong and Chaoyong He*

Department of Pharmacology and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

*Correspondance to: Chaoyong He 

 PDF  Full Text DOI: 10.25107/2474-1647.2819


As a leading cause of morbidity and mortality worldwide, Cardiovascular Disease (CVD) refers to a class of diseases occurring in heart or blood vessels. CVD includes several conditions such as myocardial infarction (heart attack) and heart stroke (heart failure). The fundamental pathological process underlying these conditions is atherosclerosis; a multi-process vascular lesion resulted from high blood pressure, hyperlipidemia and local chronic inflammatory response. Some of the lesions in later stage are vulnerable to rupture, trigger thrombosis and obstruct the blood flow of microvascular causing heart attack or stroke. Numerous stimuli and factors participate in the development of CVD including Platelet-Derived Growth Factor (PDGF). PDGF is synthesized, stored (in the alpha granules of platelets) and released by platelets upon activation. Other types of cells including smooth muscle cells, activated macrophages and endothelial cells also produce PDGF. PDGF exerts physiological functions by binding to corresponding receptors. PDGF/PDGFR signaling pathway plays a crucial role in the development of blood vessels and other organs as well as tissues. On the other hand, aberrant activation of PDGF/PDGFR signaling pathway drives the progression of cardiovascular diseases such as atherosclerosis, transplant arteriosclerosis, fibrosis, etc. However, the exact mechanism is not fully explored yet. Here we review the contemporary biomedical knowledge on the role of PDGF/PDGFR signaling and related mechanisms in promoting cardiovascular diseases.


Cite the article

Wang J, Cai D, Liu H, Tong Y, He C. PDGF/PDGFR Signaling in Cardiovascular Disease. Clin Surg. 2020; 5: 2819.

Search Our Journal

Journal Indexed In

Articles in PubMed

RAF Kinase Inhibitory Protein Expression and Phosphorylation Profiles in Oral Cancers
 PubMed  PMC  PDF  Full Text
Voice Outcomes in Laryngotracheal Stenosis: Impact of the Montgomery T-tube
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Optimal Surgical Procedure for Ovarian Metastases from Colorectal Cancer based on a Retrospective Analysis
 Abstract  PDF  Full Text
Prognostic Relevance of TERT Promoter Mutations in Tonsillar Squamous Cell Carcinoma in Association with Human Papillomavirus
 Abstract  PDF  Full Text
View More...