Factors Affecting HCC Recurrence Post Liver Resection versus Living Transplantation

Morsi Mohamed1, Wael Mansy1*, Sayed Elhendawey2, Mohamed Basyouny3 and karim Boudjema4

1Hepato-Pancreatico-Biliary Surgery Department, Zagazig University, Egypt
2General Surgery Department, Zagazig University Hospital, Egypt
3FRCS, Liver Transplant Unit, Maadi Armed Forces Medical Compound, Egypt
4Liver Transplant and Hepatobiliary Surgery Department, Rennes University, France

^*Correspondance to: Wael Mansy 

 PDF  Full Text DOI: 10.25107/2474-1647.2708

Abstract

Background: Liver resection, liver transplantation and loco-regional ablation (Radiofrequency Ablation (RFA), Microwave Ablation (MWA) and Trans-Arterial Chemo-Embolization (TACE)) are the optimal ways of HCC management. The optimal treatment for HCC has long been debated according to patient condition. Patients and Methods: A retrospective study from January 2012 till March 2019 on 118 patients with HCC (58 patients underwent Hepatic Resection (HR) and 58 patients underwent LDLT). Results: There was no significant difference between the HR group and LDLT group regarding the overall survival and disease-free survival. Overall survival at 1, 3 and 5 yrs. was 94.9%, 78% and 74.5% in LDLT group while was 89.83%, 71.19% and 62.71% in HR group respectively. Disease free survival at 1, 3 and 5yrs. was 88.1%, 62.7% and 61.01% in LDLT group while was 83.05%, 57.63% and 50.85% in HR respectively. Conclusion: In management of early stage HCC HR should be considered an alternative to LDLT. The most important factors affecting HCC recurrence were tumor behavior and preoperative AFP.

Keywords

Hepatic resection; Living donor liver transplant; Hepatocellular carcinoma; Recurrence

Cite the article

Mohamed M, Mansy W, Elhendawey S, Basyouny M, Boudjema K. Factors Affecting HCC Recurrence Post Liver Resection versus Living Transplantation. Clin Surg. 2020; 5: 2708..