Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Cardiovascular Surgery
  •  Gastroenterological Surgery
  •  Neurological Surgery
  •  Minimally Invasive Surgery
  •  Obstetrics Surgery
  •  General Surgery
  •  Orthopaedic Surgery
  •  Urology


Citation: Clin Surg. 2019;4(1):2353.Research Article | Open Access

Collagen Peptide as an Effector in Pressure Injuries Treatment in Older Adult Inpatients

Yoko Hokotachi1,2, Masako Itoh3, Masumi Akasaki3, Chiho Kai1,4, Mari Hasegawa5, Toshihide Tamura3, Satoshi Uramoto3 and Teruyoshi Amagai5*

1Administration Food Sciences and Nutrition Major, Graduate School of Human Environmental Sciences, Mukogawa Women's University, Japan
2Department of Clinical Nutrition, Takarazuka Dai-ichi Hospital, Japan
3Kikai Tokushukai Hospital, Japan
4Department of Clinical Nutrition, Higashi Kobe Hospital, Japan
5School of Human Environmental Sciences, Mukogawa Women's University, Japan

*Correspondance to: Teruyoshi Amagai 

 PDF  Full Text DOI: 10.25107/2474-1647.2353


Aim: To examine the hypothesis that Collagen Peptide (CP) is effective in the treatment of Pressure Injuries (PI) in older adult inpatients. Methods: This study was a retrospective chart review conducted at a single institution. All consecutive patients who developed PI before or after admission to a single institution between January 2013 and September 2015 were enrolled. Data collected were: 1) characteristics; 2) blood test, CRP, and serum Alb during the period of PI treatment (PPT); 3) PI, evaluated by the DESIGN-R scoring system; 4) nutrition, body weight, BMI at baseline, and energy and protein intake during PPT; and 5) outcomes, the change in DESIGN-R score during PPT (ΔD), ΔD/PPT. Subjects were divided into two groups: with or without CP supplement. All collected data were compared for PI patients in Method 1: PPT ≤ 28 days vs. >28 days and Method 2: PPT ≤ 28 days treated with CP vs. non-CP. Results: Among 2,245 included patients, the prevalence of PI and incidence of hospital-acquired PI were 2.93% and 1.69%, respectively. Result 1: PI patients with PPT ≤ vs. >28 days had the following characteristics: ≥ 89 years old, lower Alb, and a less severe PI expressed as a DESIGN-R score <10. The outcomes, expressed as PPT/ΔD and ΔD/PPT, were also significantly better. Result 2: the CPgroup had a more severe PI and, paradoxically, a significantly lower Alb and Hb at baseline. Conclusion: From our results, two conclusions were drawn: (1) PI inpatients who healed within 28 days were ≥ 89 years old, had a lower Alb, and had better outcomes, expressed by a significantly shorter PPT/ΔD. (2) PI inpatients treated with CP, who had a more severe PI and, paradoxically, a significantly lower Alb and Hb at baseline, healed within 28 days. In conclusion, CP could be a strategic agent for PI treatment for inpatients ≥ 89 years old, a lower Alb and Hb, and a DESIGN-R score <10 at baseline.


Pressure injury; Collagen peptide; Albumin; DESIGN-R

Cite the article

Hokotachi Y, Itoh M, Akasaki M, Kai C, Hasegawa M, Tamura T, et al. Collagen Peptide as an Effector in Pressure Injuries Treatment in Older Adult Inpatients. Clin Surg. 2019; 4: 2353..

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