Clinical Evaluation of Adeno-Tonsillar Hyperplasia in Non-Syndromic Children and Adolescents during Growth Hormone Treatment

Renata Nasser1 , Thalita Vervloet2 , Claudia A Eckley1 , Stefano Amade1 , Vinicius Dokkedal Silva3 , Gabriel N Pires3 , Monica L Andersen3 , Sergio Tufik3 , Carlos Longui2 , Rodolfo Scalia1 and Sandra D Xavier1,3*

Department of Otorhinolaryngology, Santa Casa Misericórdia de São Paulo, Brazil 2 Department of Pediatric Endocrinology, Santa Casa Misericórdia de São Paulo, Brazil 3 Department of Psychobiology, Federal University of São Paulo, Brazil

^*Correspondance to: Sandra D Xavier 

 PDF  Full Text DOI: 10.25107/2474-1647.3087

Abstract

Objective: To evaluate the difference in size of pharyngeal and palatine tonsils in patients aged between 5 and 17 being treated with recombinant human Growth Hormone (rhGH). Material and Methods: We conducted a prospective longitudinal observational study. Twelve patients in treatment with rhGH were evaluated by otorhinolaryngological physical examination, nasofibrolaryngoscopy and Obstructive Sleep Apnea (OSA)-18 questionnaire in two different timepoints: when selected (T0) and after 6 months (T1). Results: No significant associations were found regarding palatine and pharyngeal tonsil size with rhGH treatment. In relation to OSA-18 questionnaires, there was no statistically significant result in the absence of covariables for the general score as well as for the five domains that it comprises. When covariables were included in the analyses, controlled by the patient?s age, we observed statistically significant increases in the general score and in the domains relating to sleep disorders, emotional suffering, diurnal problems and the caretaker?s concerns. Conclusion: In the present study, pharyngeal or palatine tonsils hyperplasia was infrequent during treatment with rhGH in the non-syndromic children and adolescents. However, the impacts on sleep and quality of life that may arise warrant careful monitoring during therapy.

Keywords

Adenoids; Pathology; Child; Human growth hormone; Adverse effects; Palatine tonsil; Pathology; Sleep apnea syndromes

Cite the article

Nasser R, Vervloet T, Eckley CA, Amade S, Dokkedal-Silva V, Pires GN, et al. Clinical Evaluation of AdenoTonsillar Hyperplasia in Non-Syndromic Children and Adolescents during Growth Hormone Treatment. Clin Surg. 2021; 6: 3087..