Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Surgical Oncology
  •  Plastic Surgery
  •  General Surgery
  •  Cardiovascular Surgery
  •  Neurological Surgery
  •  Bariatric Surgery
  •  Colon and Rectal Surgery
  •  Obstetrics Surgery


Citation: Clin Surg. 2021;6(1):3086.Research Article | Open Access

Sister Mary Joseph Nodule: Analysis of a Case Series of Umbilical Metastases of Diverse Origin in a Single Centre

Clara Fernández Fernández, Alejandro Manrique Municio, Iago Justo Alonso, Virginia GarcíaMoreno and Alberto A Marcacuzco Quinto*

General Surgery and Abdominal Organ Transplantation Unit, “12 de Octubre” Hospital, Spain

*Correspondance to: Alberto A Marcacuzco Quinto 

 PDF  Full Text DOI: 10.25107/2474-1647.3086


Sister Mary Joseph nodule is an umbilical metastatic lesion. Its incidence is 1% to 3% in cases of abdominopelvic neoplasms, typically of gastrointestinal or genitourinary origin. Its presence indicates advanced malignancy. This lesion can manifest as a presenting sign as well as a revealing progression or recurrence of intra-abdominal malignancy. We analyzed retrospectively a case series of histologically diagnosed umbilical metastases in our centre between May 2010 and October 2020. The aim of the study was to analyze the clinical, analytical and histopathological characteristics of the umbilical nodules; as well as the patient survival. A total of 15 patients were diagnosed, 9 females and 6 males. The median age of diagnosis was 66 years. In 67% of cases, the finding was made at the time of diagnosis of the disease, and in 33% was a sign of recurrence or progression. Associated signs or symptoms were described in 60% of the patients. A surgical resection of the umbilical nodule was performed in 12 cases, and a core needle biopsy in 2 cases. Histological analysis revealed adenocarcinoma in 93%. The origin of the primary tumor was ovarian (53%), pancreaticobiliary (27%), bladder, mammary or prostatic. In 93% of the cases a simultaneous distant metastatic affection was histologically or cytologically confirmed. Umbilical metastasis is lesions that may go unnoticed and whose diagnostic delay could lead to a decrease in survival. Therefore, it is essential to carry out a thorough physical examination, analyze suspicious lesions and establish an individualized treatment


Umbilical metastases; Sister Mary Joseph nodule; Pancreaticobiliary

Cite the article

Fernández CF, Municio AM, Alonso IJ, García-Moreno V, Marcacuzco Quinto AA. Sister Mary Joseph Nodule: Analysis of a Case Series of Umbilical Metastases of Diverse Origin in a Single Centre. Clin Surg. 2021; 6: 3086..

Search Our Journal

Journal Indexed In

Articles in PubMed

Risk Factors for Visual Impairment in an Uninsured Population and the Impact of the Affordable Care Act
 PubMed  PMC  PDF  Full Text
Automated Sagittal Craniosynostosis Classification from CT Images Using Transfer Learning
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Clinical Effects of Using the Enhanced Recovery after Surgery (ERAS) Approach on Postoperative Bariatric Surgery Status: A Review Study
 Abstract  PDF  Full Text
Laparoscopic Versus Robot Techniques for the Choledochal Cyst in Children: An Initial Meta-Analysis
 Abstract  PDF  Full Text
View More...