Prospect on the Therapeutic Effect of Vascular Endothelial Growth Factor from the Perspective of the Pathogenesis of Pancreatitis

Muna Palikhe, Jun Zhan, Rajiv Kumar Jha and Xudong Zhang

Division of Gastroenterology, The second Affiliated Hospital of Xi’an Jiaotong University, China
Division of Gastroenterology, Xi’an Medical University, China

^*Correspondance to: Jun Zhan 

 PDF  Full Text DOI: 10.25107/2474-1647.2174

Abstract

Many theories on the pathogenesis of severe acute pancreatitis (SAP) cannot fully explain the pathophysiological mechanism of SAP, with many unexplainable contradictions, hence the need for further investigation. Vascular Endothelial Growth Factor (VEGF), the most effective proangiogenic and vascular endothelial protective agent found by far, plays critical roles in the processes of angiogenesis, vascular development and vascular protection. In recent years, many scholars have investigated the therapeutic effect of VEGF on pancreatitis, but the results are inconclusive. This study intends to explore the prospects of VEGF on the treatment of SAP from the perspective of the pathogenesis of pancreatitis.

Keywords

Acute pancreatitis; Pathogenesis; Vascular endothelial growth factor

Cite the article

Palikhe M, Zhan J, Jha RK, Zhang X. Prospect on the Therapeutic Effect of Vascular Endothelial Growth Factor from the Perspective of the Pathogenesis of Pancreatitis. Clin Surg. 2018; 3: 2174.