Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Plastic Surgery
  •  Neurological Surgery
  •  Ophthalmic Surgery
  •  Thoracic Surgery
  •  Gastroenterological Surgery
  •  Obstetrics Surgery
  •  Minimally Invasive Surgery
  •  Transplant Surgery

Abstract

Citation: Clin Surg. 2019;4(1):2344.Research Article | Open Access

Deep Survival Model Identifies Prognostic Subgroups of Triple-Negative Breast Cancer Patients

Isaac Kim, Sung Wook Seo, Jeong Eon Lee, Hee Jun Choi, Jai Min Ryu, Se Kyung Lee, Jong Han Yu, Seok Won Kim and Seok Jin Nam

Department of Surgery, Sungkyunkwan University School of Medicine, Republic of Korea
Department of Orthopedic Surgery, Sungkyunkwan University School of Medicine, Republic of Korea

*Correspondance to: Sung Wook Seo 

 PDF  Full Text DOI: 10.25107/2474-1647.2344

Abstract

Objective: The aim of this study was to develop predict model for survival of BC patients using deep learning method and to apply our model for classifying the prognostic subgroups of TNBC patients.
Methods: We enrolled 7915 patients above pathologic stage 1 among 16254 patients who underwent surgery for breast cancer between May 1996 and January 2015. The enrolled patients were randomly sorted patients into a training group (80%, n=6288) and a test group (20%, n=1627). The Survival Recurrent Neural Network (SRN) model was constructed based on logistic regression function and long short-term memory recurrent neural network.
Results: The mean area under the receiver operating characteristics curve (AUC) of validation sets was 0.780 at 1st year, 0.840 at the 2nd year, 0.857 at 3rd year, 0.869 at 4th year, and 0.834 at 5th year. The mean AUC of test set was 0.945 at 1st year, 0.861 at 2nd year, 0.834 at 3rd year, 0.825 at 4th year, and 0.805 at 5th year. The c-index of the final model was 0.810 in the test group. In addition, the precision of SRN model was evaluated for classifying TNBC patients in test group. TNBC patients were classified into subgroups by SRN-suggested survival probability. Especially in pathologic stage 3 patients, SRN guided subgroups A, B and C were more precisely classified (P value <0.0001) than conventional stage IIIA, IIIB and IIIC (P value =0.292).
Conclusion: Our SRN model provides a useful tool for survival prediction of BC patients and also divides subgroup according to survival in TNBC patients.

Keywords

Breast Neoplasm; Machine Learning; Survival

Cite the article

Kim I, Wook Seo S, Eon Lee J, Jun Choi H, Min Ryu J, Kyung Lee S, et al. Deep Survival Model Identifies Prognostic Subgroups of Triple- Negative Breast Cancer Patients. Clin Surg. 2019; 4: 2344.

Search Our Journal

Journal Indexed In

Articles in PubMed

Mesh Sprayer Device with Liquefied Mesh Delivery System: Proposed Alternative for Currently Available Meshes in Hernia Repair and Supplement to Abdominal Closure
 PubMed  PMC  PDF  Full Text
Risk Factors for Visual Impairment in an Uninsured Population and the Impact of the Affordable Care Act
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Recurrent and Refractory Ischemic Stroke Complicating Evans Syndrome
 Abstract  PDF  Full Text
PDGF/PDGFR Signaling in Cardiovascular Disease
 Abstract  PDF  Full Text
View More...