Head & Neck Spindle Cell Melanoma

Cui Ye, Feiluore Yibulaying, Lei Feng, Zhi-cheng Yang and Alimujiang Wushou

Department of Orthodontics, Shanghai Stomatological Hospital, Fudan University, China
Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, China
Department of Preventive Medicine, School of Public Health, Fudan University, China
Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, China

^*Correspondance to: Alimujiang Wushou 

 PDF  Full Text DOI: 10.25107/2474-1647.2167

Abstract

Purpose: Head Neck Spindle Cell Melanoma (HNSCM) is very rare morphologic subtype of melanoma and unexplored comprehensively. The aim of this study was to investigate HNSCM’s incidence, general demographics, basic clinico-pathologic features, and treatment outcome and disease specific prognostic factors.Material and
Methods: HNSCM cases were identified in Surveillance, Epidemiology, and End Results database (1973-2018).
Results: A total of 2500 HNSCM cases with a median age of 66 years were found in the database. The Male-to-female ratio is 2:1. Statistically significant Overall Survival (OS) and Disease Specific Survival (DSS) differences were found were depending on age, gender, race, age, tumor location, SEER historic stage, T stage, N stage, M stage and pathological differentiation (p<0.05). In the multivariate Cox regression analysis, age >66 years [Hazard ratio (HR) (95%, Confidence Interval, CI) =2.785 (2.224-3.488), p=0.000, for OS; HR (95% CI) =2.140 (1.535-2.983), p=0.000, for DSS, age ≤ 66 years as reference], unmarried status [HR (95% CI) =1.254 (1.031-1.525), p=0.023, for OS, married as reference], T3+T4 stage [HR (95% CI) =1.330 (1.080-1.639), p=0.007, for OS, HR (95% CI) =1.577 (1.106-2.247), p=0.012, for DSS, TX+T1+T2, as reference] and M1 stage [HR (95% CI) =2.658 (1.385-5.101), p=0.003, for OS, HR (95% CI) =6.894 (2.122-22.39), p=0.003, for DSS, M0 as reference] were associated with worse DSS and OS. Besides, the non-skin tumor [HR (95% CI) =0.511 (0.366-0.714), p=0.000, for OS, HR (95% CI) =0.603 (0.366-0.994), for DSS, p=0.047 skin tumor as reference] was associated with favorable DSS.Conclusion: HNSCM mostly occurred in white people at 60~80 years old with predominance in males. The patient’s age, tumor location, T stage, M stage and marital status were independent prognostic factors for DSS and OS.

Keywords

Spindle cell melanoma; Head neck; SEER analysis

Cite the article

Ye C, Yibulaying F, Feng L, Yang Z-C, Wushou A. Head & Neck Spindle Cell Melanoma. Clin Surg. 2018; 3: 2167.