Application of Octacalcium Phosphate Collagen Composite to Bone Defects in Humans: A Long-Term Observational Study

Tadashi Kawai, Tetsu Takahashi􀀔, Keiko Matsui, Yushi Ezoe, Osamu Suzuki and Shinji Kamakura

Division of Oral and Maxillofacial surgery,Tohoku University Graduate School of Dentistry, Japan
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Japan
Division of Bone Regenerative Engineering, Tohoku University Graduate School of Biomedical Engineering,
Japan

^*Correspondance to: Tadashi Kawai 

 PDF  Full Text DOI: 10.25107/2474-1647.2130

Abstract

Clinical research on octacalcium phosphate collagen (OCP/Col) application in bone defect has demonstrated its high bone regeneration ability. Herein, we conducted a long-term study involving the clinical evaluation of OCP/Col-applied cases. A successful outcome was confirmed in two patients followed up for 7 years and 6.5 years. Both cases showed stable radiographic findings of the bone tissue without any abnormal findings of the oral cavity. To our knowledge, this is the first report to confirm the long-term stability and safety of newly formed bone after OCP/Colimplantation.

Keywords

Bone regeneration; Bone substitute material; Long-term observation

Cite the article

Kawai T, Takahashi T, Matsui K, Ezoe Y, Suzuki O, Kamakura S. Application of Octacalcium Phosphate Collagen Composite to Bone Defects in Humans: A Long-Term Observational Study. Clin Surg. 2018; 3: 2130.