Application of Octacalcium Phosphate and Collagen Composite for Bone Augmentation with Sinus Floor Elevation in Humans

Tadashi Kawai, Tetsu Takahashi, Keiko Matsui, Yushi Ezoe, Fumihiko Kajii, Yoshinaka Shimizu, Shigeto Koyama, Hiroyuki Kumamoto, Osamu Suzuki, Shinji Kamakura

Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry,Japan
Toyobo Co., Ltd., Japan
Division of Bone Regenerative Engineering, Tohoku University Graduate School of Biomedical Engineering,Japan
Division of Oral Pathology, Tohoku University Graduate School of Dentistry, Japan
Tohoku University Hospital, Dental Implant Center, Japan
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Japan

^*Correspondance to: Tadashi Kawai 

 PDF  Full Text DOI: 10.25107/2474-1647.2112

Abstract

Octacalcium Phosphate (OCP) and collagen composite (OCP/Col) was recognized as a highly osteoconductive bone substitute material based on in vitro and in vivo studies. In this study, OCP/ Col was applied for bone augmentation with sinus floor elevation as a clinical trial. This study evaluated the progress of bone formation via OCP/Col and dental implant treatment. OCP/Col was applied in 3 patients, and these patients were evaluated subsequent bone formation radio graphically and examined the newly formed bone histological and via Fourier transform infrared spectroscopy. Radio graphical examination showed that OCP/Col converted to hard tissue with radiopacity within 6 months of implantation. Histological examination confirmed normal bone tissue in a specimen and FTIR revealed characteristics of bone-like apatite. There was no problem after the treatment of the dental implant. This study suggested that OCP/Col could be a bone substitute material for bone augmentation procedures involving sinus floor elevation.

Keywords

Bone substitute material; Bone augmentation; Dental implant treatment

Cite the article

Kawai T, Takahashi T, Matsui K, Ezoe Y, Kajii F, Shimizu Y, et al. Application of Octacalcium Phosphate and Collagen Composite for Bone Augmentation with Sinus Floor Elevation in Humans. Clin Surg. 2018; 3: 2112.