Multiple Pilomatrixomas: Review of Genetic Associations � The Surgeon Perspective

Adeeb Paddy Naasan, Hannah Naasan and Anas Naasan

Department of Plastic Surgery, Institute of Ninewells Hospital, UK
Department of Dermatology, Institute of Ninewells hospital, UK

^*Correspondance to: Anas Naasan 

 PDF  Full Text DOI: 10.25107/2474-1647.1957

Abstract

Pilomatrixoma, or calcifying epithelioma of Malherbe, was first described in 1880 by Malherbe and Chenantais. It is a benign neoplasm arising from hair follicle matrix cells. It usually presents as a hard subcutaneous slowly growing mass. It accounts for 1.04% of all benign skin lesions. The overlying skin is mostly skin-coloured but could be pigmented. The mass is either deeply subcutaneous and invisible or superficial with possible erosion. Bullous appearance has also been described but is rare. Multiple pilomatrixomas is found to be associated with several genetic conditions, most commonly myotonic dystrophy, Turner’s syndrome, and Gardner’s syndrome. Recent associations with MYHassociated polyposis, Rubinstein-Taybi syndrome, Trisomy 9, Sotos syndrome and sarcoidosis have also been reported in the literature. A review of the literature assessing the genetic implications for multiple pilomatrixomas is analysed. Areas for future research into some of these associations currently suggested by the literature are highlighted.

Keywords

Multiple pilomatrixomas; Pilomatrixoma; Pilomatricoma; Genetic; Skin

Cite the article

Naasan AP, Naasan H, Naasan A. Multiple Pilomatrixomas: Review of Genetic Associations � The Surgeon Perspective. Clin Surg. 2018; 3: 1957.