Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Transplant Surgery
  •  Endocrine Surgery
  •  Breast Surgery
  •  Minimally Invasive Surgery
  •  Urology
  •  Otolaryngology - Head and Neck Surgery
  •  Gynecological Surgery
  •  Colon and Rectal Surgery

Abstract

Citation: Clin Surg. 2021;6(1):3224.Research Article | Open Access

Properties Extracellular Action Potentials from Posteromedial Hypothalamus

Jesús Pastor, Lorena Vega-Zelaya and Elena Martín Abad

Clinical Neurophysiology, Hospital Universitario La Princesa, Diego de León, Spain
Foundation for Biomedical Research, Diego de León, Spain

*Correspondance to: Jesús Pastor 

 PDF  Full Text DOI: 10.25107/2474-1647.3224

Abstract

We have described the electrophysiological properties of the Extracellular Action Potential (EAP) picked up through Microelectrode-Recordings (MERs) from four patients operated under general anaesthesia at Postero-Medial Hypothalamus (PMH) by Deep Brain Stimulation (DBS) for erethism. EAPs from the same cell were pooled to obtain a mean EAP (mAP). The amplitudes and durations for all 2/3 phases were computed from the mAP, together with the maximum (dVmax) and minimum (dVmin) values of the first derivative. mAPs are denominated according to the phase polarity (P/N for positive/negative). We obtained a total 159 mAPs, all of them positive and a clear majority triphasic (89.9%) with a small P/N deflection (V1) before depolarization. The percentage of the different types of mAPs was surprisingly similar to that described recently at thalamus and although were some properties as peak-to-peak amplitude or overall duration. We observed a high correlation between absolute amplitude of the first phase (V1) and the amplitudes of either depolarization (V2) or repolarization (V3) phases, meaning that a causal relationship between them probably exists. We postulate capacitive current as responsible for V1, although it’s difficult to explain the appearing of the same polarity for the capacitive voltage and for the voltage induced by transmembrane ionic current.

Keywords

Agglomerative method; Aggressiveness; Capacitive current; Deep brain stimulation; erethism; Microelectrode recordings; Sorting spikes

Cite the article

Pastor J, Vega-Zelaya L, Martín Abad E. Properties Extracellular Action Potentials from Posteromedial Hypothalamus. Clin Surg. 2021; 6: 3224..

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