Metastasis of Breast Cancer to Renal Cell Carcinoma: A Rare Case of Tumor-to-Tumor Metastasis (TTM)

Eymen Gazel, Serdar Yalcın, Engin Kaya, Aytug Uner, Yesim Saglıcan and Lutfi Tunc

Department of Urolog, Acıbadem University, Turkey
Department of Urology, Gulhane Education and Research Hospital, Turkey
Department of Oncology, Gazi University School of Medicine,Turkey
Department of Pathology, Acıbadem University, Turkey
Department of Urology, Gazi University School of Medicine, Turkey

^*Correspondance to: Eymen Gazel 

 PDF  Full Text DOI: 10.25107/2474-1647.1935

Abstract

Objectives: The aim of this case presentation was to show a case of primary breast cancer with metastasis to renal cell cancer.
Methods: A 42-year old female patient presented with a palpable mass in both breasts and tru-cut biopsy was applied. The result of the biopsy showed in the right breast: invasive ductal carcinoma and in the left breast: mixed invasive ductal and invasive micropapillary carcinoma. In the upper pole of the left kidney, a mass of approximately 3cm was determined. With these findings, the patient was diagnosed as Grade 4 breast cancer with multiple distant metastases and chemotherapy was planned. At the end of a 10-month follow-up period, the metastases had recovered and the response of the patient to chemotherapy was reported to be good. However on the follow-up abdominal CT, there was observed to still be a mass in the mid-section of the left kidney, 2.7 cm × 2.8 cm × 3.3 cm in size, showing contrast involvement and consistent with malignancy. Laparoscopic radical nephrectomy was applied to the patient. Unclassified type RCC was determined. The general status of the patient is currently good with no recurrence and follow-up is continuing.Results and Conclusions: To date, metastasis of breast cancer has been determined in only 3 cases of resected RCC. This case is of value as the fourth case in literature of RCC metastasis from breast cancer. In conclusion, metastasis from breast cancer to RCC is not often encountered in patients. The case presented here is the 4th case of nephrectomy applied and proven breast cancer metastasis to RCC. Therefore, there is extremely limited information about the follow-up of these patients. There is a need for long-term follow-up to share the problems and treatment of these patients.

Keywords

Breast cancer; RCC; Metastasis; Oncology; Nephrectomy

Cite the article

Gazel E, Yalc?n S, Kaya E, Uner A, Sagl?can Y, Tunc L. Metastasis of Breast Cancer to Renal Cell Carcinoma: A Rare Case of Tumor-to-Tumor Metastasis (TTM). Clin Surg. 2018; 3: 1935.