Treatment of Midnight-Noon Ebb-Flow Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Patients with Multiple Myeloma

Haotian Shi, Wei Wei, Rong Peng, Haimin Chen, Nian Zhou, Lixia Wu, Dongjiao Wang, Wenjun Yu, Wenhao Zhao, Fan Zhou* and Ping Yuan*

Department of Hematologic Oncology, Shanghai Zhabei Central Hospital, China

^*Correspondance to: Fan Zhou 

 PDF  Full Text DOI: 10.25107/2474-1647.3526

Abstract

Background: Chemotherapy-Induced Peripheral Neuropathy (CIPN) seriously affects the quality of life of patients with Multiple Myeloma (MM). Midnight-noon ebb-flow acupuncture has a potential role in the treatment of CIPN, but at present there have been no randomized clinical research studies to analyze the effectiveness of acupuncture for the treatment of CIPN, particularly in MM patients. Methods: The MM patients (44 individuals) who met the inclusion criteria were randomly assigned into a solely methylcobalamin therapy group (1000 μg methylcobalamin was injected intravenously once daily) and an acupuncture combined with methylcobalamin (Met + Acu) group (methylcobalamin used the same way as above accompanied by four cycles of acupuncture). Of the patients, 39 out of 44 completed the treatment and follow-ups. The evaluating parameters included the Visual Analogue Scale (VAS) pain score, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire scores, and Electromyographic (EMG) nerve conduction velocity (NCV) determinations. We evaluated the changes of the parameters in each group before and after the therapies and made a comparison between the two groups. Results: After 112 days (four cycles) of therapy, the pain was significantly alleviated in both groups, with a significantly higher decrease in the acupuncture treated group (P<0.01). The patients’ daily activity evaluated by Fact/GOG-Ntx questionnaires significantly improved in the methylcobalamin + midnight-noon ebb-flow acupuncture group (P<0.001). The VAS in the methylcobalamin + midnight-noon ebb-flow acupuncture group improved significantly (P<0.001). Conclusion: The present study suggests that midnight-noon ebb-flow acupuncture combined with methylcobalamin in the treatment of CIPN showed a better outcome than methylcobalamin administration alone.

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Cite the article

Shi H, Wei W, Peng R, Chen H, Zhou N, Wu L, et al. Treatment of Midnight- Noon Ebb-Flow Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Patients with Multiple Myeloma. Clin Surg. 2022; 7: 3526..