The Rheological Properties of Blood in Children with Inflammatory Bowel Disease (IBD)

Levin GY, Popovicheva AN, Sosnina LN, Fedorova OV and Sheremet’ev YA

Department of Gravitation Surgery and Hemodialysis, Federal State Budgetary Institution of the Ministry of Health of Russian Federation, Nizhny Novgorod, Russia

^*Correspondance to: Levin Grigory Yakovlevich 

 PDF  Full Text DOI: 10.25107/2474-1647.1826

Abstract

The study included 37 patients aged from 6 to 17 with inflammatory bowel disease (IBD) - 17 with Crohn’s Disease (CD) and 20 with Ulcerative Colitis (UC). We investigated: erythrocyte deformability, spontaneous (shear-induced) platelet aggregation, dynamic blood viscosity, morphology of erythrocyte aggregates, the state of erythrocyte cytoskeleton by the method of thermo induction, the condition of hemostasis - using thromboelastograph analyzer TEG 5000 (USA). The results indicate that IBD is accompanied by a significant degradation of hemorheological properties of blood. It is an important factor in the pathogenesis of these diseases and lies at the core of microcirculation disorders in IBD. It was found that in CD the disorders of the majority of studied parameters is not only more significant than in UC, but also much more stable - they remained unchanged even after the treatment. Disorders of the rheological properties of blood are an important factor causing ischemic damage of the intestine. This gives grounds for recommending the use of adjuvant methods to reduce hypoxia and microcirculatory disturbances in IBD.

Keywords

Inflammatory bowel disease; Hemorheology; Blood

Cite the article

Levin GY. The Rheological Properties of Blood in Children with Inflammatory Bowel Disease (IBD). Clin Surg. 2017; 2: 1826.