Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Transplant Surgery
- Bariatric Surgery
- Surgical Oncology
- Endocrine Surgery
- General Surgery
- Cardiovascular Surgery
- Gynecological Surgery
- Neurological Surgery
Abstract
Citation: Clin Surg. 2018;3(1):1867.Review Article | Open Access
Cholecystectomy and Duodenogastric Reflux-: Reflux of Duodenal Content Induces Esophageal Carcinogenesis
Naoki Hashimoto
Department of Surgery, Kindai University, Japan
*Correspondance to: Naoki Hashimoto
PDF Full Text DOI: 10.25107/2474-1647.1867
Abstract
Cholecystectomy is a very common operation. Cholecystectomized patients have an increased reflux of bile and pancreatic juice from the duodenum to the stomach and a greater incidence of duodenogastric reflux (DGR). There is an increased chance for duodenal juice to enter the esophagus. Reflux of duodenal contents can induce mucosal injury and promote tumorigenesis. Therefore, we made a rat reflux model which was created a esophago-duodenostomy with total gastrectomy in order to permit chronic reflux of duodenal contents into the esophagus. Sever macroscopic, microscopic and molecular alterations were observed in nearly 100% of the cases after 40th weeks of chronic duodeno-esophageal reflux. Duodenal juice (especially, bile acid) has been found to induce the esophageal cancer in our animal model. Therefore, cholecystectomy is associated with a moderately increased risk of esophageal cancer, possibly by the toxic effect of refluxed duodenal juice (especially, bile acid) on the esophageal mucosa. We need to fully understand DGR to adequately advise patients on the effects of cholecystectomy.
Keywords
Cite the article
Hashimoto N. Cholecystectomy and Duodenogastric Reflux-: Reflux of Duodenal Content Induces Esophageal Carcinogenesis. Clin Surg. 2018; 3: 1867.