Review Article
Pyeloplasty the Dilemma: Open – Endoscopic – or Laparoscopic?
Shawky A EL-ABD, Mohamed G Bastawisy*, Ahmed R Ramadan and Ahmed S EL-ABD
Department of Urology, Tanta University, Egypt
*Corresponding author: Mohamed G Bastawisy, Department of Urology, Tanta University, Egypt
Published: 09 Mar, 2018
Cite this article as: Shawky A EL-ABD, Bastawisy MG,
Ramadan AR, Ahmed S EL-ABD.
Pyeloplasty the Dilemma: Open –
Endoscopic – or Laparoscopic?. Clin
Surg. 2018; 3: 1934.
Abstract
Ureteropelvic Junction Obstruction [UPJO] is defined as anatomic or functional impedance to urine flow at the ureteropelvic junction [UPJ] leading to progressive dilation of the renal collecting system. UPJO is one of the most congenital disorders of the urinary tract (1:2000 - 5000 live births). The disorder is more common in males, more on the left side, and can be found bilaterally in 10% to 40% of cases.
Etiology
The etiology of UPJO can be classified either according to onset into primary (congenital) or secondary (acquired) or, more commonly, according to the cause of obstruction into intrinsic or extrinsic. Functional or intrinsic UPJO may result from disorganization of the muscle bundles leading to failure of propagation of the peristaltic wave and transmission of urine across the UPJ. Extrinsic obstruction by a crossing vessel is a subject of a major debate and controversy [3-5].
Natural History
Initially the urinary tract responds to obstruction in a compliant way by dilatation in order to maintain a low intraluminal pressure. However, persistent obstruction evokes increased smooth muscle activity leading to muscular hypertrophy with subsequent decreased compliance and increased intraluminal pressure with its subsequent effect on GFR and parenchymal function but the outcome after correcting obstruction might be unpredictable in terms of full recovery of renal function [6,7]. Although UPJO in most of cases is a congenital disorder, its clinical presentation may be delayed till much later in life since up to 80% of cases might remain asymptomatic after birth to present later as palpable abdominal mass, recurrent urinary tract infection, flank pain particularly with diuretic states e.g. beer drinking and rarely with hematuria or azotemia in bilateral cases or UPJO in a solitary kidney.
Diagnosis
The aim is to confirm the diagnosis of obstruction, exclude mimic conditions, identify those
who can be managed conservatively from those who require intervention, and finally aid in guiding
the nature of intervention (endourologic, laparoscopic or open surgery).
Ultrasound [US]
Thanks to the wide application of routine antenatal ultrasound monitoring, the diagnosis of
UPJO is no longer a palpable flank mass in newborn, but can be achieved before birth. Antenatal
hydronephrosis [AHN], particularly UPJO, is the most common abnormality being reported in 50%
to 90% of all cases with genitourinary abnormalities [8,9]. However, it is of paramount importance
to recognize that a mere urinary tract dilatation is not equal to obstruction as there is a significant
overlap with physiological and transient hydronephrosis which are actually the most common
causes of antenatal hydronephrosis [AHN]. There is a chance for spontaneous resolution to this
dilatation but a dilated non obstructed system can be obstructed at any time even asymptomatically.
There is no golden test to diagnose obstruction in utero and, serial evaluations are usually required
but the definitive diagnosis can be only reached after birth. The Society for Fetal Urology has adopted
a classification system that relies on the degree of caliceal dilatation [10], most reports depend on
measurement of the anteroposterior diameter of the renal pelvis, a 15 mm renal pelvis dilatation was
a significant threshold to suspect obstruction in 80% of fetuses [11].
Differential diagnosis of ANH includes; transient or physiological hydronephrosis,
vesicoureteral reflux, posterior urethral valve, multicystic dysplasia, prune belly syndrome, ectopic ureter, obstructive ureterocele [8,12,13].
Postnatal US and auxiliary US procedures such as measuring
the intrarenal resistive index before and after relief of obstruction
could serve as an important predictive parameter in assessment of a
functionally significant obstruction in the UPJO patient [14,15].
Fetal Sampling and markers
Fetal serum β 2-microglobulinhas been used as an index of
fetal GFR, with modest discriminatory potential in the prediction
of postnatal GFR [16]. Other useful urinary biomarkers indicative
of the status of the obstructed kidney include; urinary matrix
metalloproteinase-9 [17,18] and urinary angiotensinogen which is
highly correlated with intrarenal angiotensin concentration [19].
In addition, karyotyping studies had shown that a DD-genotype of
angiotensin converting enzyme is indicative of a significantly greater
parenchymal damage and more rapid loss of the GFR in comparison
to those with the II or DI genotype.
Intravenous Urography [IVU]
Although intravenous urography is still considered to be the
cornerstone to outline urinary tract morphology and function in
many urologic centers, however, its role might be questionable
in the era of 3-dimensional cross-sectional imaging (CT & MRU).
Classic diagnostic findings on IVU are; variable degrees of
pelvicaliceal dilatation, delayed excretory function, with a normal or
a non-visulaized ureter. Adequate hydration with administration of a
diuretic is helpful in uncovering equivocal cases [20-23]
.
Renal scan
The role of renal scan is not only limited to patient evaluation
and defining patients in whom active intervention is required,
but also it is extended to include follow up whether an active or a
conservative treatment approach was taken. A properly performed
renal san, diuretic MAG3, provides extremely valuable functional
data on baseline differential renal function and whether a functionally
significant obstruction is present or not i.e. hydrodynamic data.
Renal scan may also play an important role in predicting the
success of active intervention; as a 3-month better functioning
unobstructed diuretic renogram predicts surgical success and that no
further evaluation is necessary [24].
Factors Affecting Successful Outcome
Since the goals of active intervention are to promote renal
drainage, preserve kidney function and resolve symptoms, failure
would be defined as inability to achieve or maintain any of these
goals. A successful treatment must be defined and based on clinical,
anatomical/morphological and functional standards. In absence of
such clear standards defining success at a certain period of follow up it
might be difficult to decide whether a further intervention is required
or not. Recently success was defined as symptomatic resolution
and relief of more than 80% of preoperative pain, either stable or
improved renal function and dilatation in the excretory urography
and improved washout from the renal pelvis on renal scan as well as a
resistance index of less than 0.7 [25].
Crossing vessel dilemma
Several controversial issues are linked to the subject of the
“crossing vessel”. Starting from its anatomical nature (normal Vs,
aberrant, Vs accessory), its clinical contribution to obstruction,
value of preoperative workup aiming to its detection with its
relation to intraoperative hemorrhagic complications when incisive
endourologic techniques are used, and finally its impact on treatment
outcome. Given the unpredictability of crossing vessel associated
with UPJO, the current recommendation of most centers is to image
preoperatively or intraoperatively before endoscopic incision using
additional imaging studies than the usual routine work up [24].
Depending on the method of imaging used, the detection rate of a
crossing vessel in patients with UPJO was 39% in patients evaluated
with conventional angiography [26,27], 40% [27] to 80% [28] in
patients evaluated with spiral CT, 53% [29] to 71% [30] in patients
evaluated with endoluminal US, and 80% in patients evaluated with
color Doppler [31].
In a prospective comparative study Keeley et al. [32] found
that endoluminal US was more sensitive than CT angiography for
identifying crossing vessels and septa between the ureter and renal
pelvis. The addition of digital subtraction and three-dimensional
image reconstruction (CT angiography, CTA) has made CTA an
attractive preoperative imaging option providing more precise
details of renal vascular anatomy. The study has achieved excellent
performance and close association to operative findings in detecting
the presence of a crossing vessel with a reported test sensitivity and
specificity of 91 % to 100%; and 97% to 100%, respectively [33,34].
MRA [Magentic Resonance Angiography] displays of renal
vascular anatomy present challenges identical to the clinical
applications of CTA. The greater spatial resolution of CTA and ability
to visualize the crossing vessel regardless of its nature (artery or vein)
over MRA favors the CT application over MRA.
During open and laparoscopic pyeloplasty a crossing vessel has
been found in ~40% of cases [36]. Crossing vessels as a cause for
UPJO; has been doubted based on several observations e.g. the high
prevalence of non-obstructive crossing vessel in many individuals
with a normal UPJ, a crossing vessel is not a constant findings in
all cases of UPJO, histologic evaluation has almost always revealed
intrinsic factors (muscular discontinuity) even when a crossing vessel
was present, and the anatomic studies based on three-dimensional
imaging concluded that crossing vasculature bears no direct relation
to the point of transition in many cases [37,38]. Last of all, crossing
vessels are more commonly observed in adults, than in pediatrics and
even less commonly observed in infants with UPJO. Since UPJO is
a congenital disorder, the infrequent finding of crossing vessels in
infants casts doubt on a vascular etiology for UPJO [36]. Crossing
vessel may influence the treatment approach and the clinical results
in several aspects. A negative impact of endopyelotomy have been
reported by Van Cangh et al. [39] as they concluded that the presence
of crossing vessels was the single most important factor for failure
of endopyelotomy as it decreased the success rate of antegrade
endopyelotomy from 86% to 42%. A number of subsequent trials had
confirmed the negative impact of the presence of a crossing vessel as
it may lower the overall success rate of endopyelotomy by 24% to 50%
[30,39], while the success rate of endopyelotomy may approach 100%
if no crossing vessel was detected on endoluminal US [40].
On the contrary, Nakada et al. [27] found that 38% of patients who
had a successful outcome 2 years after endopyelotomy had a crossing
vessel. The authors added in their conclusion that the adverse influence
of the crossing vessel is not sufficient to justify the added expense of
preoperative angiography, spiral CT or endoluminal ultrasound.
Others would consider crossing vessels to be a contraindication to
endopyelotomy which cannot correct the underlying abnormal spatial relationship between the UPJ and the offending vessel and
would recommend dismembered pyeloplasty rather than to continue
with antegrade endopyelotomy [41]. Even if endopyelotomy was
anticipated, it is crucial to avoid inadvertent injury to a crossing
vessel in order to prevent hemorrhagic complications and need for
transfusion which have been reported in up to 9% to 23% of cases
with a potential loss of functioning renal tissue since the crossing is a
segmental artery in the majority of cases [42-45].
Nature and pathology of the stricture itself
Strictures longer than 2cm are usually avascular, associated with
dense fibrosis and generally have a worse prognosis, therefore such
strictures or those associated with complete luminal obliteration are
considered a contraindication to endopyelotomy, therefore open
surgical dismembered reconstruction is preferred [46,47].
Both primary and secondary strictures are amenable to
endoscopic correction which is generally preferred in secondary
cases, and has a slightly higher success rate (84% vs. 79%) [48].
Endoscopic procedures as a repeat intervention for management
of failed prior open or laparoscopic pyeloplasty are favored due to
its minimally invasive nature. Varkarakis et al. [49] reported a 70%
success rate with a repeat intervention following a failed primary
laparoscopic pyeloplasty. Reports on the results of endopyelotomy
for 1ry or 2ry UPJO are contradicting and not conclusive, as Gupta
et al. [50] reported a higher success rate with secondary UPJO (89%
Vs. 82%), while on the contrary Matin et al. [51] reported higher
success with primary UPJO (68% Vs. 50%). It is also to be noted
that endopyelotomy following a failed pyeloplasty achieves a higher
success than a repeat endopyelotomy (71% vs. 55%) [52]. However,
laparoscopic pyeloplasty has been described as a feasible salvage
procedure for failed endopyelotpmy or open pyeloplasty with success
rates ranging from 90 to 100% without associated increased open
conversion or complication rates [53,54].
Degree of hydronephrosis
An inverse relationship between the degree of hydronephrosis
and outcome of endopyelotomy has been observed in several clinical
reports [45,55]. A marked degree of hydronephrosis or pyelocaliceal
dilatation may significantly compromise the results of corrective
procedures for UPJO. Gupta et al. [50] achieved a 96% success rate
in patients with moderate hydronephrosis vs. only 50% success in
those with a high-grade hydronephrosis. Van Cangh & Nesa (1998)
confirmed such an inverse relationship; in addition, the presence of
a crossing vessel is a further risk predictor. Endopyelotomy failure
may be as high as 95% for high-grade hydronephrosis in the presence
of crossing vessels vs. 39% failure rate for low-grade hydronephrosis
with a crossing vessel [56,57].
In cases associated with high-grade hydronephrosis, reconstructive
open or laparoscopic approach are generally recommended in order
to excise redundant parts of the renal pelvis and allow tailoring of
a dependent UPJ. However, experience from endopyelotomy series
claim that pelvic drainage following endopyelotomy may be helpful
in cases associated with redundant renal pelvis [58].
Degree of kidney function
Poor overall or split kidney function prior to endopyelotomy or
pyeloplasty is a well recognized negative predictor. Decreased urinary
flow through the corrected UPJ has been proposed as a possible
mechanism [57,59]. Generally, endopyelotomy is not advised in
kidneys with a percentage renal function < 20% [60], and nephrectomy
is recommended for poorly functioning kidneys (< 15%) [61].
Impact of early diagnosis and prenatal detection
Logically it is expected that waiting renal function to decrease in
order to do pyeloplasty, is not warranted since it does not improve
even if obstruction is corrected. However, an earlier antenatal
diagnosis would improve outcome as it allows earlier interference,
however, several clinical trials failed to reach to such conclusion.
Thomas (2008) reviewed the long-term outcome of prenatally
diagnosed urinary tract abnormalities. Congenital UPJO, unlike
posterior urethral valve, follows a benign course and the risk of
chronic or end stage renal failure is exceedingly low unless the
condition is bilateral or a solitary kidney is involved [62]. However,
the beginning of the era of prenatal diagnosis was associated with
doubling of the number of patients (age 0 to 19 years) performing
pyeloplasty although asymptomatic [63]. With a more conservative
approach many cases show a stable kidney function and it seems that
early antenatal detection has led to over treatment and performing a
quite large number of unnecessary pyeloplasty.
Management
Indications for surgical intervention in cases of ureteropelvic
junction obstruction (UPJO) include symptoms related to the
obstruction, progressive deterioration of ipsilateral renal function,
infection or the development of stones [65]. Therefore, intervention is
aimed at preservation of renal function and relief of symptom [66]. In
cases with bilateral obstruction staged procedure can be planned with
an 8 to 12 weeks interval although a double-J stent or a nephrostomy
tube to improve the less functioning kidney during correction of the
better kidney is a suitable rational.
Various surgical approaches have been developed for correction
of this condition but until now the ideal and universal treatment is
still elusive and controversial [67]. Over the past 2 decades, minimally
invasive surgery has been utilized with increasing frequency aiming
to offer less morbidity and shorter convalescent periods than open
surgery. Minimal invasive surgery included balloon disruption of
UPJ, endopyelotomy and more recently minimal access pyeloplasty
i.e. laparoscopic pyeloplasty with or without robotic assistance [68].
Open pyeloplasty
Several open reconstructive techniques have been described
but historically open dismembered pyeloplasty described in 1949
by Anderson and Hynes is the gold standard as it allows complete
excision of abnormal UPJ and reduction of the redundant renal pelvis
thus providing a widely patent, dependently positioned, well-funneled
ureteropelvic junction [66]. Stenting with or without nephrostomy
diversion has been challenging but generally it minimizes the
morbidity and improves the success. Open pyeloplasty has been used
as a template, and has gained the most universal acceptance because
it can be applied to all types of UPJO, can treat all anatomical and
pathological causes of obstruction, can be performed in most centers
by most urologist and provides a short term success between 90% to
100%, a reliable long-term success rate in excess of 90% [69]. However
pain, long lumbar incision and prolonged convalescence have been
its major drawbacks[70]. The Y-V non-dismembered modification
which is recently reported, can be performed by either routes (open
and laparoscopic), and is only suitable for the UPJO in patients with
short stenotic segment, redundant pelvis and no crossing vessels [71].
Furthermore it requires validation and longer follow up as delayed
pyeloplasty failure have been reported after laparoscopic procedure [72].
Minimally invasive techniques
Balloon dilatation of UPJ: Dilatation of UPJO is performed
under fluoroscopic control and can be performed via both antegrade
and retrograde routes. The balloon is inflated until the waiting seen
on fluoroscopy disappears. The advantage of the technique is its short
learning curve and the low risk of bleeding. However, it does not
appear to have gained popularity, as there is only a success rate of
67% to 81% [66].
Incisional techniques
Endopyelotomy: Endopyelotomy involves full thickness
incision through the obstructing ureteropelvic junction allowing
the urothelium and ureteric muscle to regenerate in a wider lumen
around a ureteric stent. The incision is usually performed laterally or
posterolaterally to avoid any crossing vessels.
In 1983, Wickham and Kellett and one year later in 1984, Arthur
Smith performed antegrade endopyelotomy via a percutaneous
approach using a cold knife. Ureteroscopic endopyelotomy soon
followed using the rigid ureteroscope. Although it was difficult to
reach the ureteropelvic junction in cases with complete obliteration
of the lumen and to use the rigid ureteroscope in all situations, the
availability of flexible instruments prompted the wider acceptance of
flexible ureteroscopic endopyelotomy [73].
This approach can be performed using either laser or diathermy
for incision either under endoscopic vision or under fluourscopic
guidance by Acucise device.
In the last two decades, endopyelotomy has been widely
performed because of its technical simplicity and decreased
morbidity. Therefore, it has supplanted open pyeloplasty as an initial
non-invasive treatment option for most adults and older children
with primary UPJ obstruction [39,42,58].
Success rates for endopyelotomy using retrograde ureteroscopic
procedure range from 73% to 90% in different series [40,45,74].
The most important factor predicting the outcome of these
procedures is patient selection. Degree of hydronephrosis, degree of
ipsilateral renal function, stricture length and the presence of crossing
vessels are all factors that should be addressed prior to intervention,
as these components have significant predictive impact on the success
after intervention [75-77].
Furthermore, several studies have shown that the presence
of a crossing vessel impacts negatively on the outcome of the
endopyelotomy [39,40,57]. However, some authors don’t agree
that this condition represent a contraindication for performing
endopyelotomy [78] or that they adversely affect the result [36].
Collectively, Butani and Eshgi reported that in selected patients
with stenosis < 2 cm, no massive hydronephrosis, and renal function
>25%, success rate of 96% with primary endopyelotomy and 85%
with secondary endopyelotomy have been achieved using cold knife
incision [79].
When comparing endopyelotomy with other treatment
options, it was found to be less invasive, requires less operating
room time, enables performing the procedure on an outpatient
basis or with a very short hospital stay, and was associated with a
shorter convalescence period [80,81], furthermore it may provide a
reasonable and successful treatment for patients who have failed open
pyeloplasty [82]. Although success rates average 82% with retrograde
endopyelotomy with no significant difference between primary and
secondary cases, the success rate falls significantly to less than 50% for
those submitted to repeated endopyelotomy. Thus, endourological
intervention after initial endourological failure has significantly
reduced success rate [82]. In contrast, a failed endopyelotomy does
not appear to adversely affect the success rate of subsequent open
pyeloplasty [83]|.
Significant intraoperative and postoperative bleeding is one of
the major concerns of endopyelotomy either antegrade or retrograde,
with an incidence of 1.2% to 9% [84]. However, Acucise, which is
a blind procedure, is theoretically claimed to have a higher risk of
bleeding from crossing vessels [85]. Kim et al. [86] reported that
bleeding was encountered in three (4%) out of 76 cases and all
patients required blood transfusion while 2 required angiography and
emolization. In a study of 40 patients with primary or secondary UPJ
obstruction randomised to be treated by laser endopyelotomy or the
Acucise device, El-Nahas and his colleagues have found after a mean
follow up of 29.9 months success rates of 85% and 65%, respectively
[87,88].
Endopyeloplasty: In a trial to provide a potential functional
superiority over conventional endopyelotomy, a horizontal suturing
of a standard longitudinal endopyelotomy incision is performed using
a nephroscope. The procedure was associated with a longer operative
time, higher functional success compared with endopyelotomy and
a successful outcome similar to those of laparoscopic dismembered
pyeloplasty. It entails an optimal full thickness healing by primary
intention without contrast extravasation outside the lumen.
Furthermore the procedure is associated with shorter duration of
stenting. The initial reports of this technique which needs certain
equipment and experience have shown a sustainable success for one
year to all cases submitted to this procedure [89].
Minimal incision pyeloplasty
Laparoscopic Pyeloplasty [LP]: Initial experience in
laparoscopic management of the obstructed UPJ has been reported
by Schuessler, Kavoussi L and Peters C. in 1993 [90]. Since that time,
better optics, instruments and greater experience in suturing have
reduced operating times to be similar to open surgery.
A high success rates following laparoscopic pyeloplasty that equal
to those of the open procedure with the advantage of the minimally
invasive techniques such as decreased pain, short hospital stay, early
return to full activity as well as avoidance of a substantial wound have
been always and frequently reported [91,92].
The procedure can be performed via both a transperitoneal and
a retroperitoneal route depending on the preference and experience
of the surgeon involved, however the operating times and success
rates are reported similar using both approaches [93]. However
with the transperitoneal procedure, the working space is larger with
clear anatomic guide marks while the retroperitoneal route provides
a direct exposure to the urinary tract and allows easy detection of
crossing vessels.
The principle difference between LP, which fulfill all principles of
open dismembered Anderson Hynes technique and its endourologic
counterparts lies in its ability to treat all patients as it addresses all
situations related to UPJO including patients with high insertion
ureter, complete luminal obliteration, significant hydronephrosis
and those with crossing vessel with no need for preoperative or intraoperative imaging to exclude these vessels, which saves time
and money [70,91]. The main drawback has been the relatively steep
learning curve, difficulty in intracorporeal suturing and knotting and
in the conversion rate to open surgery which varies from 0 to 6.4%
[66,73,94].
In a comparative study between LP and endopyelotomy [EP],
Dimarco found the success rate for laparoscopic pyeloplasty to be
significantly greater than for endopyelotomy and estimated 3, 5 and
10-year recurrence-free survival rates for EP to be 63%, 55% and 41%
compared to 85%, 80% and 75% for LP respectively [73,88,95].
Brooks and Kavoussi 1995 have reported the results of a
comparative study of open pyeloplasty versus three minimal
access treatment modalities: antegrade endopyelotomy, Acucise
endopyelotomy, and transperitoneal LP. In this retrospective and
non-randomized study the success rates with a mean follow-up
period of 21 mo were 100% for both open (n=11) and laparoscopic
pyeloplasty (n=12), 78% for Acucise endopyelotomy (n=9), and
77% for antegrade endopyelotomy (n=13). Predictably, Acucise
endopyelotomy resulted in a shorter convalescence of one week than
LP with a conclusion that LP was as effective as open pyeloplasty in
relieving UPJ obstruction, but led to a more rapid return to normal
activities.
Therefore, Laparoscopic dismembered pyeloplasty has been
settled as an excellent and reproducible management to all types of
UPJO competing open pyeloplasty the long-held gold standard. Due
to improvement in the technical skills, proven safety, effectiveness
with minimal morbidity and increased success rate to be similar to
open techniques with more than 90% in many big series, the argument
that open approach is still the gold standard is strongly debatable
particularly in equipped centers and by experienced urolaparoscopist
[25,93,96,97].
Robot-assisted laparoscopic pyeloplasty: The da Vinci robot
pyeloplasty first performed by Sung and Gill in 1995 on a porcine
model has commonly been performed transperitoneally [98] but
recently Kaouk has described retroperitoneal robotic pyeloplasty
with excellent clinical and radiological success rate. The additional
benefits of robotic surgery are free movement of joysticks that allow
free movements into seven degrees of freedom and articulations at
the tips of the instrument with motion scaling, tremor filtering, and
a magnified (×10) three-dimensional vision [70]. These advantages
can significantly facilitate precise intracorpreal both incision and
suturing and subsequently can overcome the steep learning curve
of the standard lap pyeloplasty [99]. It has been also proven as an
effective and safe reconstructive procedure for PUJO in children with
operative time approximating that of open surgery [100-102]. In a
meta-analysis reviewing robotic LP versus conventional LP, Braga et
al. [103] showed that robotic-assisted pyeloplasty is associated with a
reduction in the operative time, a slightly shorter hospital stay, and
similar complication and success rates.
Schwentner and Pelzer [104] recently reported a large experience
of the robot-assisted pyeloplasty on ninety-two patients with a mean
follow- up time of 39.1 months and a success rate of 97% based on
clinical and radiological outcomes of an IVP and MAG3 scintigraphy.
Coclusion
The overall success rate after dismembered pyeloplasty to correct
UPJO whether performed by laparoscopy, robotic assisted technique
or open surgical procedures are in the range of 90% to 100% among
most published data. While the first procedure has been linked
to those experts in laparoscopy, the second procedure is a costly
technology that fulfills the skills and the dreams of the urologists with
broader applications than pyeloplasty. The open procedure is stable
with time and has high successful outcome more than 50 years, and
can be performed in any urology center all over the world by a trained
urologist. The other non dismembered minimally invasive procedure
has not only a 10% to 25% lower successful outcome but also has
certain indications at the UPJ. Therefore, a prospective multicenteric
randomized clinical study are still needed to compare the efficacy
and long term results guided by a standard clinical and radiological
parameters to provide a relevant evidence of the efficacy of robotic
pyeloplasty relative to its high cost with all other treatment modalities
including the minimally invasive laparoscopic and open procedures.
Taking safety, morbidity and experience with availability of the
suitable equipments and cost effectiveness in consideration on the
long term success, a clear international guidelines will be helpful for
the new urologists to know, is it the time to give up open pyeloplasty
; which of these procedures and when it can be the gold standard.
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