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A Lesion Mixed with Gallbladder Neoplasm: Adenomyomatosis

Ali Ezer and Alper Parlakgumus*

*Corresponding author: Alper Parlakgumus, Department of General Surgery, Baskent University School of Medicine, Adana Teaching and Research Center, Adana, Turkey

Published: 22 Aug, 2017
Cite this article as: Ezer A, Parlakgumus A. A Lesion Mixed with Gallbladder Neoplasm: Adenomyomatosis. Clin Surg. 2017; 2: 1600.


Gallbladder; Neoplasm; Adenomyomatosis

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Gallbladder adenomyomatosis (GAM) is a benign disorder distinguished by mucosal epithelium proliferation and muscularis mucosae hypertrophy and frequently characterized by the formation of mucosal invagination in the hypertrophied muscular is and intramural diverticula or sinus tracts which is significant in radiological monitoring (Rokitansky-Aschoff sinuses). It is also referred as ‘cholecystitis glandular proliferans’ in literature [1]. A 72 years old female patient applied to the hospital with occasionally increasing stomach pain. Her blood test results were as follows; T bil: 0, 3 mg/dL, D. bil: 0, 1 mg/dL, ALP: 84 U/L, CEA: 0, 75 ng/ mL, CA 19-9: 17, 15 U/ mL, GGT: 9 IU/L. (found normal). Ultrasonography findings revealed that an 18x17 mm hypoechoic lesion existed on the gallbladder wall involving calcification and cystic spaces and was evaluated in support of focal adenomyomatosis. A mass lesion with soft tissue density reaching approximately 16 mm in diameter was found in the gallbladder at the fundus portion on CT results of the patient and this lesion was thought to be in compatible with gallbladder adenomyomatosis (Figure 1a and 1b). In the history of the patient, she was diagnosed with sigmoid volvulus and sigmoid colon resection was applied on her. The patient was taken into operation and open cholecytectomy was practiced. Intra-operative frozen section examination was performed. No malignity was identified. Adenomyoma at the fundus portion was reported on pathology examination. The patient was discharged from hospital on the post-operative 2nd day without any problems. In cases where the possibility of malignity cannot be completely distracted, MR imaging aids to get a diagnosis. With selected cases, PET examination helps to distract malignity [2]. With regard to gross characteristics, Jutras et al. [3] categorize the gallbladder adenomyomatosis into three types: segmental, localized or generalized. Segmental type adenomyomatosis is reported to have relation with malignity especially in old patients [3,4]. The case we present here is an example for a localized type adenomyomatosis. It should always be kept in mind that gallbladder adenomyomatosis might be confused with malign lesions and this possibility should always come to mind in definitive diagnosis. On old patients suspected with malignity, surgical intervention is the first-choice treatment in gallbladder adenomyomatosis.

Figure 1a
Figure 1b

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Figure 1a
Figure 1b

The axial view of an abdominal computered tomography of the patient showing localized type adenomyomatosis of gallbladder settled in fundus (red arrow).
The coronal view of an abdominal computered tomography of the patient showing localized type adenomyomatosis of gallbladder settled in fundus (red arrow).


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