Review Article
Postoperative Management of Vascular Surgery Patients: A Brief Review
Minati Choudhury*
Department of Cardiac Anesthesia, Cardiothoracic Sciences Centre, AIIMS, New Delhi, India
*Corresponding author: Minati Choudhury, Department of Cardiac Anesthesia, Cardiothoracic Sciences Centre, AIIMS, New Delhi-110029, India
Published: 07 Aug, 2017
Cite this article as: Choudhury M. Postoperative
Management of Vascular Surgery
Patients: A Brief Review. Clin Surg.
2017; 2: 1584.
Abstract
Atherosclerosis is an inflammatory condition leading to various cardiovascular as well as
cerebrovascular events and peripheral vascular disease (PVD). Presence of significant atherosclerosis
leads to perioperative adverse events, morbidity and mortality in the high risk surgical population.
The usual methods for evaluating the like hood of adverse cardiovascular or cerebrovascular events
postoperatively in these set of patients depends primarily on scoring system and functional status
of the cardiovascular system during preoperative assessment. The pre existing disease activity and
possible postoperative adverse cardiovascular event (CVE) can be estimated to some degree from
the preoperative levels of biomarkers associated with atherosclerosis. This mini-review summarizes
the potential role of biomarkers related to the atherosclerosis process in the cardiovascular risk
stratification of patients undergoing non cardiac surgery. A Med Line search of literature on
atherosclerosis biomarkers in the perioperative period and adverse post operative cardiovascular
event was conducted; and thirty-three reports are added to this review.
Keywords: Vascular surgery; Postoperative period
Introduction
In spite of a great potential development in patient selection expert technical execution of operations and anticipation of complications, vascular surgery patients are not free from some dreaded complications during their postoperative course. Early identification and management of the complications is essential to improve the overall outcome of these patients. The commonly used scaring systems such as American Society of Anesthesiologists classifications and the Lee Revised Cardiac Index to quantify postoperative complications are most useful in identifying low risk patients only [1,2]. Hence, appropriate decision making regarding the need for intensive care after vascular surgery are the key to high quality patient care during their post operative period. This mini review elaborates the general principles of post operative care, complications and their management in a vascular surgery patient.
When the Care Starts? and Who are Most Vulnerable?
Shifting of a post operative (PO) vascular surgical patient from operating room (OR) to intensive care unit (ICU) is critical and has an increased risk of morbidity and mortality, despite a relatively short distance involved. This risk is minimized by careful planning, proper team involvement and selection of appropriate monitoring aids during transport. There are several factors involved in postoperative complications and postoperative care after vascular surgery eg. the type and extent of surgery, extreme age, associated co-morbidities [(especially coronary artery disease(CAD), chronic obstructive pulmonary disease, obesity, sleep apnea, chronic heart failure and chronic renal failure],emergency surgery and preoperative cardiopulmonary status of the patient.
What is Special in Postoperative Monitoring of a Vascular Surgery Patient?
Post operative vascular surgery patient are at risk of development of abnormal physiology and its consequences even if they have a normal hemodynamic during the pre operative period. Twenty five percent of the patients suffer from limb ischemia, which needs a continuous pulse oxymetry monitoring. A Doppler examination gives a better clue to diagnosis and immediate thrombectomy or lytic therapy with secondary endovascular or open surgical intervention is required in such cases [3]. In a study of 185 patients undergoing vascular surgery, a 12 lead ECG with ST segment analysis showed transient myocardial ischemia in 21% and myocardial infarction (MI) in 6.5% [4]. Leads placed in V3 and V5 are more predictive and the combination of two precordial leads give greater than 95% sensitivity when compared with troponin level for post operative ischemia monitoring. These patients should be considered for measurement of post operative troponin level even if there is no ECG evidence of ischemia. Arterial pressure monitoring site should depend upon the type of aortic surgery and one should not forget the variables that affect the systolic and diastolic pressure measurements (eg. length of the tubing). One should remember that the mean arterial pressure is a more accurate reflection of mean aortic pressure. Central Venous pressure evaluation puts light and sense to manage the patients with immediate unwanted chest X-ray findings and elevated beta natriuretic peptide (BNP) levels, administer vasoactive drugs and to asses intravascular volume. In comparison to the normal surgical patients, major vascular surgical cases have a two to three fold greater risk of myocardial ischemia when core temperature is < 35ºC. Warmed inhaled gases and infused liquids have some benefit in warming these patients. Echocardiography is an essential component of postoperative monitoring that can diagnose complications eg. cardiac tamponade, distinguish right and left ventricular function and adjust therapy accordingly e.g. patients with poor IV function can be benefited from inotropes, where as a hypodynamic empty ventricle needs volume therapy [5]. High intra-abdominal pressure (IAP)>15 mmHg, leading to intra abdominal hypertension (IAH) is one of the major predictor of abdominal compartment syndrome (ALC) and cause of mortality after surgery in thoraco abdominal aorta (TAA) [6]. Therapeutic interventions based on IAP measurements, such as restoration of volume status and abdominal compression may be important in reversing multiorgan failure and preventing further harm. Patients with IAP below to mmHg generally do not have ACS, while those with an IAP>25 mmHg usually have ACS. A higher systemic blood pressure may maintain oxygen perfusion when IAP is increased. Symptomatic patients with confirmed diagnosis of ACS need supportive scare and at times surgical intervention. Monitoring of mesenteric perfusion is essential in some specific situations like e.g. supracoeliac clamp, IAH, athermanous diseases of superior mesenteric artery, and during massive vasopressure requirement. Monitoring of Glasgow comma scale status and transcranial Doppler is essential after carotid end arterectomy where as monitoring of cerebrospinal fluid (CSF) pressure and volume is needed in patients who have the risk of development of spinal cord ischemia during the PO period e.g. TAA aneurysm (TAAA) repair, extensive stent cover are below T 9, occlusion of subclavian or hypogastric artery. Cardiac troponins (Tn) and brain natriuretic peptide (BNP) are two commonly estimated biomarkers in vascular surgical patients. An increased concentration of BNP is associated with major adverse cardiac events where as elevated Tn denotes the presence of myocardial ischemia.
Adverse Postoperative Events and Special Care
Acute hypertension is common after vascular surgery and the
goal is to identify the causative factors and reduce the diastolic
BP over a period of 30-60 minutes ultra short acting/short acting
antihypertensives and adequate analgesia. Hypertensive patients
mostly develop natriuresis hence fluid should be administered along
with anti hypertensive [7]. The hypotension following vascular surgery
needs immediate attention as it is associated with an increased risk of
multi organ failure, graft thrombosis and possible renal failure. The
two management strategies for hypovolemia include administration
of volume depending upon the deficit and vasoactive agent.
However, a surgical cause should always be excluded. Arrhythmias
mainly occur in patients with structural heart disease and common
triggers are similar to any other surgical patients. Tachyarrhythmias
are most common are of diagnostic challenge. On the other hand,
bradyarrhythmias do not require any treatment in the absence of
hemodynamic instability [8,9]. Up to 48% of vascular surgery patients
develop ischemic events post operatively [10]. It has been seen that
elevated level of myocardial enzymes following vascular surgery are
associated with increased mortality at 6 months. Once the ischemia
is diagnosed rapid resuscitation should be done with supplemental
oxygen, timely use of β-blockers, after load reduction agents, anti
platelets, anticoagulants and percutaneous coronary intervention.
Post operatively fibrinolysis is a relative contraindication, but this
decision must be individualized to the patients according to the
extent of surgery and time after operation. In the presence of clinically
significant ischemia or cardiogenic shock, urgent revascularization is
needed. A change in ST segment is the most sensitive indicator of post
operative myocardial ischemia. The accepted ST segment changes
used to detect myocardial ischemia is >0.1 mV measured 80 ms from
J point. Post operative ST segment changes with a prolonged duration
(>6 min per episode/>2 hr cumulative length) are independent
predictor of post operative cardiac events.
Echocardiography can best detect abnormal wall motion and
new regional wall motion abnormalities giving a clue to development
of ischemia. An ischemic event lead to prominent a and a waves in
Pulmonary Artery (PA) wave form, increased LVEDP and increase
PA pressure which are again the sensitive indicators of myocardial
ischemia.
In general, many question relating to perioperative
pharmacological therapy to prevent post operative MI following
vascular surgery remains unanswered. Future studies are needed
to determine which patients required intensified post-operative
surveillance, medical therapy, and/or coronary intervention to
improve long term survival following vascular surgery.
Intra Abdominal Complications and Management
Intraabdominal complications are rare but potentially lethal after
TAAA or AAA repair and carry an overall mortality of 40%-45%.
Mesenteric vascular ischemia leading to gangrene of the gut, small
bowel obstruction, pancreatitis, intestinal ischemia, aortoesophageal
fistula, aortoenteric fistula, acute cholecystitis, chylopertoneum,
mechanical obstruction to the gut, colonic infarction, ascites, ischemic
colitis and liver dysfunction are some of the IA complications
following vascular surgery those needs attention. Prolong
Cardiopulmonary Bypass (CPB), aortic cross clamp time along with
intraoperative surgical complications can cause low cardiac output,
hypo perfusion and ischemic injury to the gut [11]. Among all the
gut ischemia, colonic infraction is difficult to diagnose because of
patients poor physical status. Confirmatory diagnosis can be made
by colonoscopy and the overall mortality is as high as 89% is one of
the series [12,13]. For all the gut ischemia, conservative treatment
with local vasodilatation often helps. Non-respondent may undergo
specialized approach that considers surgical and endovascular
options for better outcome. Potential intraabdominal infection and
pancreatic injury are the potential causes of acute pancreatitis and
the therapeutic options ranges from restrictive regime to radial
necrostomy and multiviseral resection. Chlylous ascites is common
following AAA surgery because of anatomical relation of cistern chyli
to abdominal aorta. Paracentesis, improvement in total parenteral
nutrition provides the possibility of an extended period of oral starvation that reduces the lymphatic flow from the leaking gut. In
case of failure of conservative treatment placement of peritonealvenous
shunt/ transfixing the damaged lymph vessels and omentum
plasty are some options [14]. The devastating complications like
aortoesophageal or aorto bronchial fistula can occur late in the post
operative period. Post operative respiratory and renal dysfunctions
are significant predictors of this complication according to some
authors [15]. A close follow of may diagnose these complications early,
although there is no evidence that early detection can improve the
prognosis. Both surgical and endovascular treatment are associated
with high mortality but conservative treatment is not a viable option.
Esophageal stent grafting/esophageal reconstruction, meditational
drainage or even endoscopic use of fibrin glue at the level of fistula
is some proposed management protocol for these patients. Post
operative liver dysfunction following aortic aneurysm repair may
occur due to prolong surgical time, preoperative hepatic injury and
massive blood transfusion. The management protocol is routine as
per any other patient having post operative liver dysfunction. Massive
post operative bleeding is not unusual and the causes can be surgical,
decrease in coagulation factors and residual heparinization. The most
basic principles of management of meditational or intraabdominal
bleeding following major aneurysm repair are: i) rule out surgical
bleeding, ii) measure the hemoglobin and hematocrit, iii) diagnose the
underlying medical causes hematocrit, iii) Diagnose the underlying
medical causes by coagulation tests, iv) check the sign of adequate
perfusion to the vital organs and, v) restore clothing factors to normal
by means of medications(i.g. tranexamic acid recombinant factor
VII, aminocaproic acid), normothermia and by transfusion of blood
products [16]. Liberal blood transfusion during vascular surgery is
no longer supported because of high rate 30 days’ adverse events in
these group of patients. Transfusion above hemoglobin of 9 gm/dL is
not advocated by most of the authors [17]. If large volume is required
for transfusion, balanced salt solution is preferred over normal saline
to reduce the development of iatrogenic hyperchloremic metabolic
acidosis. The decision to transfuse platelet concentrate must not be
based exclusively on platelet count but also take into account the
patients clinical condition, in particular when fever >38.5° centigrade,
presence of coagulation disorders, prolong CPB and ongoing
oozing. The main indication for transfusion of fresh plasma (FFP)
is correction of deficiencies of clotting factors in a bleeding patient
for which a specific concentrate is not available. The recommended
initial dose is 10-15 ml/kg of body weight and a maximum dose up
to 30 mg/kg can be administered depending on the patient’s clinical
situation and laboratory parameters. What is most important again,
“do not use FFP as a volume expander” Consider the administration
of cryoprecipitate only in the presence of severe hypofibrinogenemia
(>1 gm/dL) despite treatment with FFP.
The prevalence of post operative hyperglycemia is high among
vascular surgery patients. Krinsley in one of his retrospective review
demonstrated that hospital mortality was directly related to the mean
glucose value and nearly doubled in those with a mean glucose level
of 140-159 mg/dL [18]. Post operative hyperglycemia occurs in 21%-
34% of patients within 72 hrs of surgery. Previous studies have shown
that for every 40 mg/dL increase in PO glucose level leads to a 30%
increase risk of infection, graft failure and longer ICU stay [19]. The
American Association consensus statement 2005 regarding inpatient
glycemic control, defined hyperglycemia as a blood glucose value
>140 mg/dL and hypoglycemia as a blood glucose value < 70 mg/dL.
Treatment of hyperglycemia in the ICU should begin with an
intravenous insulin infusion with a starting threshold not higher than
180 mg/dL, although some benefit may realized at lower target level
[20]. No randomized trials specially addressing the monitoring and
treatment of PO hyperglycemia during major vascular surgery have
been performed. Therefore, results of studies in comparable patients
groups usually translated for the management of current population.
The usual advice is, moderate tight glucose control with a target blood
glucose level of 110-140 mg/dL could be more beneficial. Severe
ischemia to kidney leading to acute renal failure (ARF) is common
especially after TAAA repair. Even if the incidence of this complication
has fallen over time, it still remains as a major cause of mortality in
this group of patient. The incidence of ARF is highest in ruptured
AAA (20%-29%) and lowest in infrarenal AAA (0%-13.9%) [21]. The
occurrence of ARF increases with the addition of following inciting
factors: emergency surgery, proximal aortic repair, preoperative renal
dysfunction adverse intraoperative and PO events and co-morbidities.
The mortality of ARF requiring renal replacement therapy after repair
of intact or ruptured AAA is 58%-86% and likely represents the
mortality list associates with ARF as a part of multiorgan dysfunction.
What is more important again, the distinction between ARF of
hypovolemic /cardiogenic origin. The former needs fluid resuscitation
along with blood or blood products if required, while the later require
improvement in myocardial performance. Post renal dysfunction due
to obstruction of urinary tract by injury or compression by graft/limb
is uncommon, acute in onset, can be diagnosed by renal ultrasound
and confirmed by retrograde urography. Therapy may require
placement of urethral stents or percutancous nephrostomy. Patients
with prostate hypertrophy or an epidural catheter for pain control
may have acute urinary retention leading to obstructive uropathy and
removal of bladder catheter difficult. To avoid urinary retention in
such cases 6-12 hr time is allowed to elapse after epidural analgesia is
discontinued prior to removal of urinary catheter. It is always ideal to
prevent the development of ARF with some preoperative and
intraoperative measures especially in the patients who care
particularly at more risk. The diagnosis of ARF is based on an acute
rise of serum creatinine and blood urea nitrogen (BUN) with or
without a concomitant decrease in urine output. However, creatinine
and BUN are relatively insensitive markers of excretory renal
function. The glomeular filteration rate may fall by 50% before a rise
in serum creatinine can happen due to kidney’s compensatory
increase in creatinine excretion. An organized plan of diagnosis and
treatment is important while dealing with the patients with ARF after
vascular surgery. If correction of filling pressures or myocardial
performance fails to improve urinary output, evaluation of other
causes of oliguria should be done. The conversion of oliguric renal
failure to a non-oliguric state may delay the need for renal replacement
therapy and simplify fluid management. It may be associated with
fewer complications and improved survival although prospective
data to support this notion is lacking. Vascular surgery patients
requiring chronic renal replacement therapy have a grave prognosis.
Use of continuous veno-venous hemofiltration and dialysis is
recommended until patient’s hemodynamic status is stabilized.
Continuous hemodialysis reduces hemodynamic instability allows
better control of fluid and metabolic status, removes the deleterious
cytokines and thereby affects the outcome. The dose of renal excreted
medications should be adjusted. Nutritional support of the patients
with ARF is important as protein-calorie malnutrition is common in
these patients. Finally, a frank discussion regarding the prognosis of
these patients with their family member is essential. Major vascular
surgery, requiring prolong CPB enhances the release series of inflammation mediators and stress hormones which alters body
metabolism and subsequent release of glucose, amino acid and free
fluid fatty acids to the circulation so that substrates are in part diverted
from the purpose they serve in non stressed state to the task of raising
an adequate healing response [22]. These patients at times required
extensive laparotomy or retroperitoneal exposure involving
mobilization of viscera and nasogastric tube drainage for several days
post operatively. Large volume of fluid transfusion during the post
operative period may lead to weight gain edema, paralytic ileus and
delayed gastric emptying. Restriction of fluid to the amount needed to
maintain salt, electrolyte and water balance lead to fast return of
gastric emptying and can be capable of tolerating normal food and
have normal bowel movements several days earlier than those in
positive balance. However, this claim has not been consistently
supported by later studies. Preoperative carbohydrate loading to
combat the fasting state has been shown to enhance post operative
recovery by causing improved protein balance, improved preservation
of lean body mass and length of hospital stay in general surgical
patients. However, literature is missing for vascular surgical cases in
this context. The main goal of nutritional support in vascular surgery
patients is to minimize negative nitrogen balance by avoiding
starvation, with the purpose of maintaining muscle, immune and
cognitive function and to enhance post operative recovery. Oral
feeding should be started as soon as possible after surgery provided
that there are no signs of ileus. After elective TAAA repair, gastric
emptying has been shown to return by 18 hrs and normalization of
small bowel function by 47 hrs. If oral feeding is not possible, other
means of nutrition should be implemented. Management of nutrition
is a major concern especially for patients who undergoes AAA repair,
needs high dose of opioid analgesia or prolonged mechanical
ventilation. It has also been suggested that routine fluid and
carbohydrate loading 2 hrs before surgery can alternate post operative
insulin resistance and patient well being. Some authors suggested that
excess of intravenous fluids in particular normal saline may contribute
to post operative gastrointestinal dysfunction; prolong post operative
stay and adverse clinical outcome [23]. Some patients also undergo
enforced bed rest, not only as a part of traditional care but also
because of the presence of drips, catheters and drains. Within this
pattern of post operative care patients are subject to a period of
starvation and immobilization that last for minimum of 4-5 days. In
order to combat the nutritional consequences, nasogastric
nasoenteral nutritional is preferred because it is associted with fewer
infection and metabolic complications than parenteral nutrition.
Enteral made is however contraindicated in the presence of
intolerance, risk of aspiration and associated bowel obstruction. Oral
feed should be started as early as possible once bowel sound is return
and there is no vomiting or sensation of nausea. Parenteral nutrition
is only indicated if gut cannot be used or the patient failed enteral
nutrition despite the use of pro kinetic agents. Effective and adequate
pain management is important not only to keep the patient
comfortable, but also to reduce post operative complications as well
as chronic pain syndrome. Though commonly used opiods have a
concern over their side effects, especially potential respiratory
depression and hypotension. Epidural analgesia is an effective method
of pain control especially after TAAA repair, but hard to use because
of existing post operative coagulopathy. In a Cochrane review report
a Meta analysis of 13 randomized trials involving 1224 patients
having abdominal aortic surgery 597 of which were treated using
systemic opiates and rest epidural analgesia. The authors noticed that
those receiving epidural analgesia had significantly fewer
cardiovascular complications and renal insufficiency. They too spent
20% less time in mechanical ventilation and reported less subjective
pain. No mortality difference was reported. However, those potential
benefits were associated with increased cost and increased risk of
epidural hematoma [24]. Routinely used method of analgesia and
epidural analgesia usually interfere with neurologic assessment. Use
of paravetebral analgesia has been described by few authors which
provides unilateral analgesia, less incidence of pulmonary
complication, urinary retention, nausea, vomiting and hypotension
than epidural block with a similar pain score. Because of the difficulty
in pain control, multimodal therapeutic strategy provides central or
peripheral block associated with non steroidal (NSAID) and adjuvant
is now the cornerstone of treatment, offering the possibility of
reducing opioid requirement and side effects. Use of NSAID may
decrease post operative morphine consumption by 30%-50% and
nausea, vomiting by 29%. However, the incidence of respiratory
depression remains the same. Concerns over bleeding gastrointestinal
ulceration, renal injury, and cardiac ischemia/infarction have limited
the widespread utilization of NSAIDS in vascular surgery. Other
multimodal adjuncts include but not limited to ketamine, pregabaline
and gabapentin. Though various dosing regimens of these adjuncts
have been narrated for post operative analysia, no single standard has
been defined. The use pregabaline and gabapentin in major vascular
surgery is yet to be reported. Cryo analgesia is successful in the
immediate post operative period, has been abounded for its brief
duration and increase incidence of chronic pain. At the end the
decision making process about optimal approach towards pain
control should be multimodal and a combine one between surgeon
and anesthesiologist.
The risk of deep vein thrombosis (DVT) among these patients
ranges from 0%-20.5%. Elderly age, morbid obesity, prolongs surgery
and positive family history is the usual predisposing factors [25].
Prophylaxis is generally given until patients become ambulatory.
Early ambulation, leg exercise, graduated compression stocking and
intermittent pneumatic compression are extensively used method.
Some authors also tried venous foot pumps with good results. Among
the various pharmacologic methods in fractionated heparin reduces
the rate of DVT with minor bleeding complications by more than
50%. The usual dose in 5000 units 2 hrs before surgery followed by
10,000-15,000 U/24 hr. Five percent of these patients develop heparin
induced thrombocytopenia, thrombosis and ischemic complications.
The oral vitamin K antagonist warfarin is most commonly used
drug administered in low fixed doses and does not require
extensive laboratory monitoring. A prolongation of prothrombin
time corresponding to an INR between 2.0 to 3.0 is considered be
adequate for DVT prophylaxis following vascular surgery. Factor
Xa inhibitors e.g. fondaporinus and indraparinus, direct thrombin
inhibitors e.g. hirudin and dabigatran are rarely used. Revaroxiban
for DVT prophylaxis is under phase III trial. The use of combination
of mechanical and pharmacologic method improves the DVT
development. These two methods are complementary rather than
competitive. DVT prophylaxis therapy however is not free from
heparin induced thrombocytopenia (HIT) and thrombosis. Once HIT
is diagnosed and alternative anticoagulation with direct thrombin
inhibitors/ heparinoids has to be started. The goal is to reduce platelet
activation and thereby reduce the risk of thrombin formation. If the
patient had thrombosis transition to warfarin should occur once
platelet counts have recovered above 150,000/mm3 and treatment
should be maintained for 3-6 months. Pulmonary complications are significant cause of morbidity after major vascular surgery and
cause significant prolongation of hospital stay. As most of the patient
need prolong mechanical ventilation a lung protection strategy to
be used to reduce ventilator induced lung injury. Application of
PEEP is unknown, but accepted range defends upon the clinical
situation [26]. Patients who are at increased risk of volutrauma, may
need low tidal ventilation. The main disadvantage of this strategy is
decreased clearance of carbon dioxide and respiratory acidosis, but
this permissive hypercapnea and acidosis is well tolerated if the pH
is >7.2. One caveat is that permissive hypercapnea is contradicted in
patients with cerebral edema. The major predicting factors for post
operative respiratory dysfunction after vascular surgery are; extreme
age, co-morbidities, abnormal pulmonary function test, extensive
surgery, prolong sedation and muscle relaxant use, post operative
hypothermia, fluid over load in proper post operative analysia
bronchioles and airway secretion. All these factors predisposes
to early airway closure and atelectasis leading to V/Q mismatch,
hypoxia, retained secretion and respiratory failure. Prevention of
these complications should be initiated during the preoperative
period which includes lung expansion maneuvers e.g. deep breathing
exercise, antibiotic prophylaxis to decontaminate nasopharynx.
Apart from continuation of the above two procedures post
operatively adequate pain control, early weaning trial, maintenance
of euglycemia i.g. tight glucose control (80-110 mg/dl) is important
to prevent nosocomial pneumonia. Selective decontamination of
the digestive tracts and drainage of subglottic secretion may lessen
the incidence of pneumonia. Spontaneous breathing trails without
progressive withdraw/may fasten extubation. A successful trial is
evidenced by the absence of respiratory distress (respiratory rate
>35 for >5 minutes or oxygen desaturation < 90% for 10 seconds),
increase or decrease in heart or blood pressure (± 20% >5 min) or
signs of agitations or distress. A patient with difficult airway needs
special attention. Failure to extubation is associated with increased
mortality and need for long term ventilation. Tracheostomy is reserve
for patients who require prolong ventilator support e.g. presence of
pneumonia, severe cardiovascular instability neurological deficit
patients with absent of cough reflex. Percutaneous tracheostomy is
safer than often surgical method, however contraindicated in patients
who are hypoxic, have high PEEP requirement, obese patients with
short neck, presence of coagulopathy and in those with recent (< 10
days) cervical spine fixation. Neurological injury spinal resulting
from spinal cord ischemia or cerebral ischemia is not uncommon
after major vascular surgery. Subdural hematoma paraplegia,
cerebrovascular accident, brain stem infarction, vision disturbances,
sensory or motor deficit of the arm or leg are some of the noted
neurological injury reported after major aneurysm surrey. In a
prospective randomized trial Coselli et al. showed that perioperative
CSF drainage up to 10 mm Hg reduces the rate of paraplegia after
Crawford type I and II TAAA [27]. A spinal drain is inserted
(usually at L4-L5) interveterbral space by many anesthesiologists for
continuous drainage of CSF and monitoring of CSF pressure during
the perioperative period. For a correct CSF pressure measurement,
the line should be calibrated and zeroed independently of all pressure
transducers and the plug connection to be double checked. The spinal
drain should never left open to the collecting beg as the inadvertent
sudden drainage of a large volume of CSF may cause precipitous fall
in intracranial pressure and lead to tearing of subdural vessels within
patients skull, leading to cerebral damage from subdural hematoma.
To reduce the risk of hematoma, CSF drain placement should be done
before systemic heparinization and management should be exercised
with ultimate care, diligence and caution. CSF is generally drain in
10 ml of increments with a goal of CSF pressure < 10 mm Hg and
the drainage should continued for at least 48-72 hr post operatively
to minimize neurological deficit. During CSF drainage, the MAP
is usually maintained between 80-100 mmHg. If the CSF pressure
>10 mmHg it is drained to a limit of 15 ml/hr when the patient is
neurologically intact. If delayed, neurological deficit occurs; CSF is
drained without limit to maintain pressure 5 mmHg, provided there
is no visible blood in CSF. The incidence of post operative delirium
is approximately 22% in vascular surgery patients according to one
group of authors. These patients are relatively older and more likely
had a history of transient ischemic attack, cerebrovascular accident or
have pre operative β blocker therapy. Statin administration reduces
the risk by 44%. Paraplegias usually developed by PO day 1-3 after
TAAA repair. Some intraoperative precaution like manipulation of
perfusion pressure, sequential clamping/minimization of duration of
cross clamp, intercostals reattachment, hypothermia, continuation
of CSF drainage and manipulation of spinal cord perfusion pressure
with a lumbar spinal drain during postoperative period are the
standard postoperative care to reduce this complication.
Special Care for the Patients with Carotid Surgery
These patients should be observed for 4-6 hrs post operatively. Immediate attention should be given to those developed neurological deficit and in case of non availability of carotid scanning patient should be assumed to have developed carotid artery occlusion and taken back to the operating room without delay. Cerebral hyperperfusion syndrome secondary to uncontrolled postoperative hypertension is better controlled by IV labetolol 5 mg increment up to 100 mmHg maximum [28]. Bleeding and hematoma at site of carotid surgery may lead to progressive airway obstruction in the perioperative period and need urgent evacuation of the hematoma. Hypotension following carotid surgery occurs in 5 % patients and responds well to volume and phenylephrine infusion. Significant non respondent hypotension in presence of high filling pressure may warrant the possibility of development of myocardial infarction. The incidence of intracerebral hemorrhage following carotid surgery varies between 50-93 % and can be prevented with a controlled blood pressure. Hemodynamic ally compromised patient may developed seizure which is identified with close monitoring.
Pregnant Patients Need Additional Care
Pregnant patient who undergo major vascular surgery need special care because of the physiological changes in pregnancy. Shu C et al. [29] managed three cases of type. B aortic dissection treated with endovascular stent repair of thoracic aorta either before after delivery. One of the patient developed type II endovascular leak that required a left common carotid artery stent.
When to Discharge from ICU?
Premature discharge may increase the mortality to 40% according to various studies. Though most of the centers have their own discharge criteria’s, the standard ones include: hemodynamic stability without the need for a vasoactive agent, Hb> Sgm/dL adequate analgesia to make patient active, urine output>0.5 ml/mg hr with normal renal biochemistry and no indication for further surgical intervention.
Conclusion
Despite a substantial improvement in postoperative care following major vascular surgery, there need development of some improved strategies to identity the patients at risk for post operative MI, management of psychological aspect of patient and relatives as well as development cost effective ICU stay in patients with open repair.
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