The Association of Physiological Factors and Biochemical Factors with Different Progress Phage of Diabetic Retinopathy in Type 2 Diabetes Patients

Songhe Li and Dacheng Wen

Department of Gastrointestinal Nutrition and Hernia Surgery, The 2nd Hospital of Jilin University, China
Department of Ophthalmology, The 1st Hospital of Jilin University, Changchun, China

^*Correspondance to: Songhe Li 

 PDF  Full Text DOI: 10.25107/2474-1647.3728

Abstract

Diabetic Retinopathy (DR) stands as a prevalent and consequential microvascular complication of Diabetes Mellitus (DM), holding the unfortunate distinction of being the primary cause of blindness in individuals affected by DM. As such, a pressing need exists to thoroughly investigate the implications of various physiological and biochemical risk factors across distinct phases of the disease. This exploration is crucial for shaping the diagnostic and therapeutic strategies employed in the management of DR. While prior research has established connections between DR and factors such as Body Mass Index (BMI), blood glucose levels, Glycated Hemoglobin (HbA1c), Serum Creatinine (Scr), Uric Acid (UA), and β2 Microglobulin (β2-MG), the exact influence of these factors on varying stages of DR progression remains unclear.
Our study constitutes a pioneering effort to delve into the divergent manifestations of DR across its different progression stages, specifically regarding physiological and biochemical elements. The implications of this study hold tremendous promise in terms of reducing both the incidence rate and the potential for vision loss among patients grappling with DR. Our findings indicate that the severity of Moderate Non-Proliferative DR (NPDR) is notably exacerbated by increased BMI, Scr, and β2-MG levels. Similarly, the progression to Severe NPDR is closely associated with advancing age, elevated blood glucose levels, heightened Scr, and UA concentrations. Furthermore, the risk of Proliferative DR (PDR) escalates with rising BMI, blood glucose levels, HbA1c, and β2-MG concentrations. Notably, age, blood glucose, HbA1c, Scr, UA, and β2-MG have all been identified as prominent risk factors shaping the trajectory of DR in patients.

Keywords

Physiological factors and biochemical factors; Diabetic retinopathy; Type 2 diabetes

Cite the article

Li S, Wen D. The Association of Physiological Factors and Biochemical Factors with Different Progress Phage of Diabetic Retinopathy in Type 2 Diabetes Patients. Clin Surg. 2025; 10: 3728..