Connections Between Endoplasmic Reticulum Stress and Prognosis of Hepatocarcinoma

Wu M, Yan J, Qin S, Fu L, Sun S, Li W, Chen L* and Lv J*

College of Bioinformatics Science and Technology, University of Harbin Medical, Harbin, China

^*Correspondance to: Junjie Lv 

 PDF  Full Text DOI: 10.25107/2474-1647.3725

Abstract

Endoplasmic Reticulum (ER) stress is a stress condition in which misfolded or unfolded proteins accumulate in the ER lumen due to some exogenous or endogenous factors. It has a significant impact on cell survival, proliferation, and metastasis in cancer, all of which are aspects of the pathogenesis of malignancies. ES stress genes have currently been used as drug targets for cancer therapy. The objective of our research was to create a model for Hepatocellular Carcinoma (HCC) utilizing ER stress-related Genes (ERGs). A prognostic model was built by screening ERGs that showed differential expression and significant survival. External datasets successfully validated the effectiveness of the model. Based on risk scores, groups at high and low risk were categorized. Functional analysis showed risk groups involved in the unfolded protein response, DNA repair, and other differential pathways. Compared to low-risk patients, the prognosis for HCC patients in the high-risk group might worsen because of disruptions in these pathways. Importantly, we considered genomic druggability and predicted drugs. Sorafenib induced autophagy in HCC cells through an ES stress mechanism. Sorafenib was more sensitive for high-risk patients. In brief, our model predicted the prognosis of HCC and provided novel treatment strategies for the study of other cancers.

Keywords

Endoplasmic reticulum stress; Hepatocellular carcinoma; Prognostic model; High risk

Cite the article

Wu M, Yan J, Qin S, Fu L, Sun S, Li W, et al. Connections Between Endoplasmic Reticulum Stress and Prognosis of Hepatocarcinoma. Clin Surg. 2024; 9: 3725..