Liver Transplantation Subsequent to Liver Resection for Collision Tumors in VHC Cirrhotic Patient

Cadar R, Năstase A, Trofin AM, Zabara M, Ciobanu D, Vasiluta C, Blaj M, Vlad N*, Ursulescu-Lupașcu C and Lupașcu C

II General Surgery and Liver Transplant Clinic, University Hospital “Saint Spiridon” Iasi, Romania University of Medicine and Phamacy “Grigore T. Popa” Iasi, Romania Histopathology Clinic, University Hospital “Saint Spiridon” Iasi, Romania Department of Anesthesia and Intensive Care, University Hospital “Saint Spiridon” Iasi, Romania Radiology Clinic, University Hospital “Saint Spiridon “Iasi, Romania

^*Correspondance to: Nutu Vlad 

 PDF  Full Text DOI: 10.25107/2474-1647.3699

Abstract

Liver transplantation is a well-established indication for hepatocarcinoma developed in end-stage liver disease; however, the indications for liver transplantation still controversial. This combined type of tumor lesion follows an aggressive clinical course with an unfavorable prognosis. The clinical outcome of orthotopic liver transplantation in patients with Hepatocellular Carcinoma (HCC) is well defined, but its role in the management of cHCC-CC remains largely unknown. Herein, we present the case of a 50-year-old female patient with Hepatitis C virus-related cirrhosis who received antiviral treatment two years prior to admission to a surgical clinic where she was admitted for an imagistic finding of two focal hepatic lesions measuring 4.5 cm and 1.5 cm, in the liver segments 6. At the admission the patient presented low level of thrombocytes (102,000 mm3 and slightly elevated alpha-fetoprotein serum level (31.3 ng/ml) and she was classified as score Child-Turcotte – Pugh A6. After surgery, the patient was listed for liver transplant, and one year later, a proper donor was found. The liver transplant procedure was uneventful. Histopathological examination of the cirrhotic liver revealed a recurrence of hepatocellular carcinoma. In conclusion, liver transplantation should be considered for combined cholangiocarcinoma and hepatocarcinoma after liver resection because of the risk of tumor recurrence.

Keywords

Liver transplantation; Cholangiocarcinoma; Hepatocarcinoma; Recurrence; Collision tumor

Cite the article

Cadar R, Năstase A, Trofin AM, Zabara M, Ciobanu D, Vasiluta C, et al. Liver Transplantation Subsequent to Liver Resection for Collision Tumors in VHC Cirrhotic Patient. Clin Surg. 2024; 9: 3699..