Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Colon and Rectal Surgery
  •  Oral and Maxillofacial Surgery
  •  Orthopaedic Surgery
  •  Minimally Invasive Surgery
  •  Neurological Surgery
  •  Robotic Surgery
  •  Thoracic Surgery
  •  Plastic Surgery


Citation: Clin Surg. 2024;9(1):3680.Research Article | Open Access

Efficacy and Safety of Verapamil Intralesional Injection in Peyronie’s Disease Using the Kalsi Technique

Saleh B, Dallash M, Koura M, Ibrahim M and Kalsi J

Department of Urology, Frimley Health NHS Foundation Trust / Wexham Park Hospital, UK

*Correspondance to: Bassam Saleh 

 PDF  Full Text DOI: 10.25107/2474-1647.3680


Objectives: To assess the efficacy and safety of Intralesional Verapamil Injections (ILV) as a minimally invasive treatment option for patients with Peyronie’s Disease (PD), and to describe the procedure technique. Materials and Methods: Patients with chronic phase PD and an inability to have penetrative intercourse were started on the ILV treatment protocol after thorough counselling about the treatment plan and alternative treatment options. A direct questionnaire was used to assess the study outcomes in terms of improvement in penetrative intercourse and any post-procedure side effects. The degree of penile angulation was also visually measured to the nearest 10° during an artificial erection at the beginning of treatment then regularly prior to each treatment session. Results: 26 patients have either completed the six-injection protocol or had enough improvement with a lower number of injections. The penile curvature ranged from 30° to 90°, with a median of 50.3°. Twenty patients had a curvature of a 45° or more. Nineteen patients (73%) reported satisfactory post procedure improvement in their ability to achieve penetration. Conclusion: Our study strongly supports the use of ILV as a non-invasive treatment option that can “in carefully selected patients” provide a significant subjective and objective improvement in pain, penile deformity, degree of curvature and sexual function with no significant side effects. We believe that ILV should be offered as a first line option to patients with Peyronies disease with a significant curvature. It is especially helpful in patients who already have a degree of erectile dysfunction.


Cite the article

Saleh B, Dallash M, Koura M, Ibrahim M, Kalsi J. Efficacy and Safety of Verapamil Intralesional Injection in Peyronie’s Disease Using the Kalsi Technique. Clin Surg. 2024; 9: 3680..

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