Efficacy and Safety of Verapamil Intralesional Injection in Peyronie’s Disease Using the Kalsi Technique

Saleh B, Dallash M, Koura M, Ibrahim M and Kalsi J

Department of Urology, Frimley Health NHS Foundation Trust / Wexham Park Hospital, UK

^*Correspondance to: Bassam Saleh 

 PDF  Full Text DOI: 10.25107/2474-1647.3680

Abstract

Objectives: To assess the efficacy and safety of Intralesional Verapamil Injections (ILV) as a minimally invasive treatment option for patients with Peyronie’s Disease (PD), and to describe the procedure technique. Materials and Methods: Patients with chronic phase PD and an inability to have penetrative intercourse were started on the ILV treatment protocol after thorough counselling about the treatment plan and alternative treatment options. A direct questionnaire was used to assess the study outcomes in terms of improvement in penetrative intercourse and any post-procedure side effects. The degree of penile angulation was also visually measured to the nearest 10° during an artificial erection at the beginning of treatment then regularly prior to each treatment session. Results: 26 patients have either completed the six-injection protocol or had enough improvement with a lower number of injections. The penile curvature ranged from 30° to 90°, with a median of 50.3°. Twenty patients had a curvature of a 45° or more. Nineteen patients (73%) reported satisfactory post procedure improvement in their ability to achieve penetration. Conclusion: Our study strongly supports the use of ILV as a non-invasive treatment option that can “in carefully selected patients” provide a significant subjective and objective improvement in pain, penile deformity, degree of curvature and sexual function with no significant side effects. We believe that ILV should be offered as a first line option to patients with Peyronies disease with a significant curvature. It is especially helpful in patients who already have a degree of erectile dysfunction.

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Cite the article

Saleh B, Dallash M, Koura M, Ibrahim M, Kalsi J. Efficacy and Safety of Verapamil Intralesional Injection in Peyronie’s Disease Using the Kalsi Technique. Clin Surg. 2024; 9: 3680..