Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Bariatric Surgery
  •  Pediatric Surgery
  •  Oral and Maxillofacial Surgery
  •  Colon and Rectal Surgery
  •  Transplant Surgery
  •  Gastroenterological Surgery
  •  Thoracic Surgery
  •  Breast Surgery

Abstract

Citation: Clin Surg. 2023;8(1):3663.Research Article | Open Access

Clinical Progression and Outcomes of Glioma Patients Infected with COVID-19

Chen J

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China

*Correspondance to: Jianbin Chen 

 PDF  Full Text DOI: 10.25107/2474-1647.3663

Abstract

Background: Patients with cancer were susceptible to COVID-19 have been reported in previous study. The clinical progression and outcomes of patients with glioma infected COVID-19 have not been reported until now. Methods: We included all patients with glioma infected with COVID-19 who was admitted to Wuhan Tongji Hospital in China in this retrospective study. We also enrolled glioma patients without COVID-19 at the same time as controls. We collected and analyzed clinical data from medical records and evaluated outcomes for patients with glioma infected with COVID-19. Cox proportional hazard model was used to evaluate whether the infection with COVID-19 was independent risk of progression for glioma. Results: From January 19th to April 01st, 2020, ten patients with glioma infected with COVID-19 and forty glioma patients without COVID-19 were included in this study. The incidence of COVID-19 in glioma patients with was 0.52% (10 of 1926 COVID-19 total hospitalizations). Often patients, four had low-grade glioma, three had grade III glioma, two had Glioblastoma (GBM), and one had medulloblastoma, with a mean age of 58 ± 18.3 years (range 13-71 years). Clinical symptoms were fever (nine (90.0%) patients), cough (six (60%) patient), anhelation (five (50%) patients), diarrhea (one (10.0%) patient) and muscle pain (one (10.0%) patient). One patient with GBM progressed to ARDS and died of severe respiratory failure, one patient with GBM was transferred to the ICU because of progression to ARDS, and the remaining eight patients were discharged. The Cox regress analysis showed that progression-free survival of glioma patients without COVID-19 was significantly longer than glioma patients with COVID-19. (Hazard Ratio (HR) 0.083, 95% Confidence Interval (CI) 0.007-0.960, P=0.046). Conclusion: Our findings suggested that progression-free survival of glioma patients without COVID-19 was significantly longer than glioma patients with COVID-19. Patients with glioma infected with COVID-19 were higher risk to deteriorate in progression than those patients without COVID-19 during follow-up period.

Keywords

COVID-19; Glioma; Progression; Outcomes; Survival analysis

Cite the article

Chen J. Clinical Progression and Outcomes of Glioma Patients Infected with COVID-19. Clin Surg. 2023; 8: 3663..

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