Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Colon and Rectal Surgery
  •  Plastic Surgery
  •  Surgical Oncology
  •  Neurological Surgery
  •  Urology
  •  Thoracic Surgery
  •  General Surgery
  •  Ophthalmic Surgery


Citation: Clin Surg. 2023;8(1):3660.Clinical Image | Open Access

Corneal Neurotization in the Setting of Previous Orbital Radiation Therapy

Fan J, Goldberg H, Anthony C and Esmaeli B

Department of Plastic Surgery, Orbital Oncology & Ophthalmic Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

*Correspondance to: Bita Esmaeli 

 PDF  Full Text DOI: 10.25107/2474-1647.3660


A 55-year-old man, a renal transplant patient with immunosuppression, presented with left midface squamous cell carcinoma with perineural spread to the skull base, leading to left corneal anesthesia and facial paralysis. His tumor was deemed surgically unresectable. He was treated with chemotherapy and high dose orbital and skull base radiation (total dose of 68 Gy). He had progressive corneal scarring and opacification despite upper eyelid weight placement, ectropion repair, and tarsorrhaphy (Figure 1A). He underwent Corneal Neurotization (CN) with sural nerve autograft coapted to the contralateral supraorbital trunk (Figure 1B), leading to marked improvement in corneal health and visual function (Figure 1C). CN is a relatively new surgical procedure for treatment of neurotrophic keratopathy [1,2]. Patients with multiple cranial neuropathies secondary to skull base tumors are at risk for severe corneal complications due to coincidence of facial paralysis and corneal anesthesia [3,4]. To our knowledge, this is the first case documenting CN in a patient who has had high dose orbital radiation therapy. CN has been thus far viewed as contraindicated after high dose orbital radiation. Coaptation of the sural nerve to the non-radiated contralateral supraorbital nerve was done as the ipsilateral supraorbital nerve was damaged from previous exposure to high dose radiation. Our patient experienced marked improvement in corneal health after CN.


Cite the article

Fan J, Goldberg H, Anthony C, Esmaeli B. Corneal Neurotization in the Setting of Previous Orbital Radiation Therapy. Clin Surg. 2023; 8:3660.

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