Comparison of Laboratory Data Between Pediatric Patients with Enuresis Nocturna and Healthy Children: A Prospective Clinical Study

Ekici O1 and Gul A2*

1Department of Urology, Nusaybin State Hospital, Turkey
2Department of Urology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Turkey

^*Correspondance to: Abdullah Gul 

 PDF  Full Text DOI: 10.25107/2474-1647.3633

Abstract

Background: To investigate whether there is a difference in the parameters of blood and urine tests of pediatric patients with and without Monosymptomatic Enuresis Nocturna (MEN). Methods: Pediatric patients aged 5 to 18 years who applied to the urology outpatient clinic with primary MEN between January 2022 and November 2022 and were started on desmopressin were prospectively included in the study. Age-matched pediatric patients who applied for right flank pain without detectable pathology were included in the control group. Urine density, pH, leukocyte (WBC), erythrocyte (RBC) and bacterial counts, Leukocyte Esterase (LES) positivity, and nitrite positivity of the patients were recorded at the time of admission. Sublingual desmopressin was started in all enuretic patients. Serum sodium, potassium and chlorine values, and results of complete urinalysis of the enuretic patients were recorded within 3 to 7 days after desmopressin treatment, and control groups at admission. Complete urinalysis and blood electrolytes of both groups were compared. Results: A total of 267 patients were included in the study. The mean age of the patients was 9.48 ± 3.27 years, the mean urine pH was 6.0 ± 0.6, and the mean urine density was 1018.1 ± 9.1. The patients were allocated to enuretic (Group 1, n:122) and non-enuretic control (Group 2, n:145) group. There was no statistically significant difference between the two groups in terms of age, sodium and chlorine values in blood, nitrite positivity in urine test, bacterial count and pH values. Gender, LES positivity, RBC, WBC counts, potassium values in urine and urine density were significantly different between both groups. According to the ROC analysis, the cut-off value for urine density, which was different between the enuretic and non-enuretic group, was 1019.5 with the 54.5% sensitivity, 61.5% specificity and 0.578 of AUC value (95% CI = 0.509-0.642, p=0.029). Conclusion: Urine density was found lower in children with MEN than those without.

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Cite the article

Ekici O, Gul A. Comparison of Laboratory Data Between Pediatric Patients with Enuresis Nocturna and Healthy Children: A Prospective Clinical Study. Clin Surg. 2023; 8: 3633..