Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Pediatric Surgery
- Oral and Maxillofacial Surgery
- Surgical Oncology
- Gastroenterological Surgery
- Orthopaedic Surgery
- Emergency Surgery
- Gynecological Surgery
- Robotic Surgery
Abstract
Citation: Clin Surg. 2022;7(1):3540.Research Article | Open Access
What to do with Gastroparetic Patients? A Systematic Review of Treatment Options
Daniel Eckhardt and Moustafa Elshafei*
Department of General, Visceral and Thoracal Surgery, University Hospital Nuremberg, Paracelsus Medical University, Germany
*Correspondance to: Moustafa Elshafei
PDF Full Text DOI: 10.25107/2474-1647.3540
Abstract
Introduction: Gastroparesis is a chronic functional disorder including nausea, vomiting, bloating, abdominal pain, early satiety and postprandial fullness [1–4]. Several treatments have been reported, e.g. G-POEM, gastric electrical stimulation or pyloroplasty. There exist some metaanalysis of one of these treatments each, yet they do not compare all of them [5,6]. Methods: We extracted data from studies on intrapyloric Botox injection, G-POEM and gastric electric stimulation and calculated significance of mean differences according to Random-effects- Model including DerSimonian-Laird test (p<0.05). Results: Nutrition, pharmacotherapy and surgical treatments couldn`t be analyzed due to missing data or minor quality of data. We stated a significant reduction of 4.9 ± 0.48 in total GCSI in pre/ post Botox injection comparison, so did G-POEM`s mean GCSI (1.651 ± 0.144). 4 h -scintigraphies of G-POEM participants illustrated a significant decrease in gastric emptying scintigraphy (26.932% ± 2.442%). The most impressive effect occurred after implantation of a gastric electric stimulator: TSS scores decreased significantly in short and long term, as well as by comparing ON and OFF mode. Discussion: Comparing all these therapies, gastric electric stimulation seems to be the most successful option according to our findings. Our recommendation is, due to heterogeneity of data, moderate [6]. G-POEM and intrapyloric Botox injections are evidence based treatments according to our and others' findings [5]. Further studies, especially on the impact of combined therapies as well as on step up approaches are necessary.
Keywords
Cite the article
Eckhardt D, Elshafei M. What to do with Gastroparetic Patients? A Systematic Review of Treatment Options. Clin Surg. 2022; 7: 3540..
