Amyloid Goiter in Renal Transplantation and Chronic Systemic Diseases; Literature Review with Six Case Reports

Ayberk Dursun1*, Gizem Kilinc1, Emel Ebru Pala2, Cem Karaali1 and Ismail Sert1

1Department of General Surgery, Izmir Tepecik Education and Research Hospital, Turkey
2Department of Pathology, Izmir Tepecik Education and Research Hospital, Turkey

^*Correspondance to: Ayberk Dursun 

 PDF  Full Text DOI: 10.25107/2474-1647.2918

Abstract

Purpose: Amyloid goiter is defined as diffuse enlargement of thyroid gland due to extensive amyloid accumulation. In this study, we aimed to emphasize the features of our patients diagnosed with amyloid goiter, which are different from the classical literature, and to review the general literature. Methods: The cases diagnosed as amyloid goiter between 2005 and 2019 were analyzed retrospectively. The etiological and demographic characteristics of patients diagnosed with amyloid goiter after clinical and pathological examination were investigated. A literature review was conducted and the results were compared. In our hospital, inadequacy in diagnosing preoperative amyloid goiter was detected and the results were discussed in the multidisciplinary endocrinology council to raise awareness. Results: Six patients were included in the study. All of the patients (100%) were male and their average age was 49.5. Compression symptoms occurring in five patients (83.3%) were the most common symptom. Three of six patients (50%) had hyperthyroidism and three (50%) had euthyroid disease. Secondary amyloidosis was detected in all cases. Three patients (50%) had kidney transplants history for various reasons. The current study differs from the literature due to the fact that all patients are male and hyperthyroidism is predominant. Conclusion: Amyloid goiter is defined as diffuse enlargement of thyroid gland due to extensive amyloid accumulation. If possible, diagnosis of amyloid goiter should be made with FNAB, and if the complaints do not improve with symptomatic treatment, surgical treatment is the only option.

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Cite the article

Dursun A, Kilinc G, Pala EE, Karaali C, Sert I. Amyloid Goiter in Renal Transplantation and Chronic Systemic Diseases; Literature Review with Six Case Reports. Clin Surg. 2020; 5: 2918.