Upfront Treatment Modality May Have Prognostic Significance in Patients with Local/Locally Advanced Stage Pancreatic Cancer

Ahmet Taner Sumbul1*, Ali Murat Sedef1, Ahmet Sezer1 and Huseyin Cem Onal2

1Department of Medical Oncology, Baskent University Medical School, Adana, Turkey
2Department of Radiation Oncology, Baskent University Medical School, Adana, Turkey

^*Correspondance to: Ahmet Taner Sümbül 

 PDF  Full Text DOI: 10.25107/2474-1647.2850

Abstract

Background: Cancer of the exocrine pancreas is highly lethal malignancy and the fourth leading cause of cancer related death in the worldwide. Systemic chemotherapy, radiation therapy and concomitant chemoradiotherapy are used as adjuvant treatment following surgical resection and provide survival benefit. The aim our study is to evaluate the prognostic significance of treatment options/sequences and clinical features in patients with local/locally advanced stage pancreatic cancer. Material and Methods: In this study we retrospectively evaluated the prognostic significance of treatment modalities in local/locally advanced stage pancreatic cancer. A total of 64 patients have been treated in Baskent University Adana Research and Training Hospital between 2007 and 2018 included into our study. Results: The median age of the patients was 61 (range 31 to 81) years and 42 (65.6%) of patients were male. The median follow-up time was 16 months and 46 (71.9%) of patients were died during follow-up. Disease-Free Survival (DFS) and Overall Survival (OS) were founded as 8, 18 months, respectively. Fifty-one (79.7%) of patients’ disease recurrence after treatment. There were statistically significant differences in median OS and DFS between T stages (p=0.001 and p=0.002, respectively). Patients who underwent surgery had better OS and DFS than whose did not go surgery (p=0.000 and p=0.000, respectively). The best survival results were founded in the group treated with ‘’surgery + CRT + CT’’ sequence. Conclusion: In our study, we showed that treatment modalities, basal CA19.9 levels and T stage of tumor may have prognostic significance in patients with local/locally advanced stage pancreatic cancer.

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Cite the article

Sumbul AT, Sedef AM, Sezer A, Onal HC. Upfront Treatment Modality May Have Prognostic Significance in Patients with Local/Locally Advanced Stage Pancreatic Cancer. Clin Surg. 2020; 5: 2850..