Immunohistochemical Analysis of Neuronal Cell Markers of Filum Terminale in Tethered Cord Syndrome

Ahmet Şükrü Umur1*, Nurcan Umur2, Seren Gülşen Gürgen3 and Mehmet Selçuki4

1Department of Neurosurgery, Manisa Celal Bayar University, Manisa, Turkey
2Department of Molecular Biology, Manisa Celal Bayar University, Manisa, Turkey
3Department of Histology and Embryology, Manisa Celal Bayar University, Manisa, Turkey
4Department of Neurosurgery, Tinaztepe University, Izmir, Turkey

^*Correspondance to: Ahmet Şükrü Umur 

 PDF  Full Text DOI: 10.25107/2474-1647.2758

Abstract

Purpose: Filum Terminale (FT) is a fibrotic anatomical structure at the caudal end of the spinal cord. Structural changes in the FT can also be the cause of Tethered Cord Syndrome (TCS), which causes traction and stress in the spinal cord. The aim of this study is to show the neuronal cell markers Brain-Derived Neurotrophic Factor (BDNF), Glial Fibril Acidic Protein (GFAP), Nestin, Noggin in the FT samples of patients with TCS by comparing them with the samples obtained from normal cadavers. Methods: In the study, FT groups were determined; as control FT group which is obtained from cadaver and TCS patients. GFAP, BDNF, Nestin and Noggin expressions in FT samples were shown by using immunohistochemistry technique. Results: According to our study, we noted that neuronal cell markers GFAP, BDNF, Nestin and Noggin were expressed in the control group especially in the ependymal cells surrounding the central canal and continue to decrease in the TCS. Conclusion: Identification of neuronal cell markers in the control filum terminale and their change in Tethered Cord Syndrome will provide important information in understanding the mechanisms underlying this disease.

Keywords

Tethered Cord Syndrome; BDNF; GFAP; Nestin; Noggin

Cite the article

Umur AŞ, Umur N, Gürgen SG, Selçuki M. Immunohistochemical Analysis of Neuronal Cell Markers of Filum Terminale in Tethered Cord Syndrome. Clin Surg. 2020; 5: 2758..