New Potential Therapeutic Strategy of Pancreatic Cancer via Targeting the Tumor Microenvironment

Chen Ye, Gang Li, Abuduhaibaier Sadula, Dian-Rong Xiu* and Chun-Hui Yuan*

Department of General Surgery, Peking University Third Hospital, China

^*Correspondance to: Chun-Hui Yuan 

 PDF  Full Text DOI: 10.25107/2474-1647.2704

Abstract

Pancreatic cancer is one of the most lethal types of cancers, with an overall five-year survival rate of less than 5%. Radical surgical resection remains a potential cure for this refractory disease but only a small number of patients could be benefit from surgery. The interactions between pancreatic cancer cells and stromal cells induce the formation of immunosuppressive and desmoplastic tumor environment and contribute to tumor progression, chemoresistance, and immune escape. In this review, we describe majority of the acellular and cellular components of tumor microenvironment and specifically review the importance of them in TME. Additionally, we discuss the most promising therapeutic strategies for targeting those components or reshaping the pancreatic tumor stroma. Finally, current clinical trials and novel investigational agents for pancreatic cancer targeting components of the microenvironment are also briefly evaluated.

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Cite the article

Ye C, Li G, Sadula A, Xiu D-R, Yuan C-H. New Potential Therapeutic Strategy of Pancreatic Cancer via Targeting the Tumor Microenvironment. Clin Surg. 2020; 5: 2704..