Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Bariatric Surgery
  •  Breast Surgery
  •  Vascular Surgery
  •  Minimally Invasive Surgery
  •  Obstetrics Surgery
  •  Oral and Maxillofacial Surgery
  •  Gastroenterological Surgery
  •  Robotic Surgery

Abstract

Citation: Clin Surg. 2020;5(1):2704.Review Article | Open Access

New Potential Therapeutic Strategy of Pancreatic Cancer via Targeting the Tumor Microenvironment

Chen Ye, Gang Li, Abuduhaibaier Sadula, Dian-Rong Xiu* and Chun-Hui Yuan*

Department of General Surgery, Peking University Third Hospital, China

*Correspondance to: Chun-Hui Yuan 

 PDF  Full Text DOI: 10.25107/2474-1647.2704

Abstract

Pancreatic cancer is one of the most lethal types of cancers, with an overall five-year survival rate of less than 5%. Radical surgical resection remains a potential cure for this refractory disease but only a small number of patients could be benefit from surgery. The interactions between pancreatic cancer cells and stromal cells induce the formation of immunosuppressive and desmoplastic tumor environment and contribute to tumor progression, chemoresistance, and immune escape. In this review, we describe majority of the acellular and cellular components of tumor microenvironment and specifically review the importance of them in TME. Additionally, we discuss the most promising therapeutic strategies for targeting those components or reshaping the pancreatic tumor stroma. Finally, current clinical trials and novel investigational agents for pancreatic cancer targeting components of the microenvironment are also briefly evaluated.

Keywords

Cite the article

Ye C, Li G, Sadula A, Xiu D-R, Yuan C-H. New Potential Therapeutic Strategy of Pancreatic Cancer via Targeting the Tumor Microenvironment. Clin Surg. 2020; 5: 2704..

Search Our Journal

Journal Indexed In

Articles in PubMed

Risk Factors for Visual Impairment in an Uninsured Population and the Impact of the Affordable Care Act
 PubMed  PMC  PDF  Full Text
Sildenafil Transiently Delays Early Alveolar Bone Healing of Tooth Extraction Sockets
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Prognostic Factors Influencing Interventional Embolization for Ruptured Intracranial Aneurysms
 Abstract  PDF  Full Text
PROZ is a Biomarker for Progression of Early Hepatocellular Carcinoma and Correlated with Tumor- Infiltrating Immune Cells
 Abstract  PDF  Full Text
View More...