Complete Resection of Post-Chemotherapy Residual Tumor Could Improve the Prognosis in Extragonadal Germ Cell Tumor

Tsutsumi S, Kobayashi K, Yasui M, Tatenuma T, Noguchi G, Osaka K, Umemoto S, Ito H and Kishida T

Department of Urology, Kanagawa Cancer Center, Japan
Department of Thoracic Surgery, Kanagawa Cancer Center, Japan

^*Correspondance to: Sohgo Tsutsumi 

 PDF  Full Text DOI: 10.25107/2474-1647.3220

Abstract

Background: We investigate the effects of chemotherapy and surgical treatment on the extragonadal germ cell tumor of which poor prognosis has been reported. Methods: We analyzed the prognosis of 31 patients with extragonadal germ cell tumor treated at Kanagawa Cancer Center by factors including patient background, the condition of disease, and treatments. Result: As the prognostic factors for the overall survival, pulmonary metastasis at the first visit (p=0.011), no normalization of tumor markers after induction chemotherapy (p=0.014) and no residual tumor resection irrespective with (p=0.03) or without (p=0.001) normalized tumor makers were significantly poor prognosis in the univariate analysis. On the other hand, patients who underwent residual tumor resection with un-normalized tumor markers (desperation surgery) tended to show a better prognosis compared to previous reports. Conclusion: Although this was an investigation in a rather small group, regardless of the tumor markers normalization, resection of a residual tumor showed the tendency of improving the prognosis of extragonadal germ cell tumor. It was considered that resection of a residual tumor with a high degree of expertise could lead to better treatment outcomes.

Keywords

Male neoplasms; Germ cells; Embryonal prognosis; Surgery testicular neoplasms

Cite the article

Tsutsumi S, Kobayashi K, Yasui M, Tatenuma T, Noguchi G, Osaka K, et al. Complete Resection of Post- Chemotherapy Residual Tumor Could Improve the Prognosis in Extragonadal Germ Cell Tumor. Clin Surg. 2021; 6: 3220..