Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Pediatric Surgery
  •  Oral and Maxillofacial Surgery
  •  Gastroenterological Surgery
  •  Transplant Surgery
  •  Cardiovascular Surgery
  •  Vascular Surgery
  •  General Surgery
  •  Minimally Invasive Surgery


Citation: Clin Surg. 2021;6(1):3054.Review Article | Open Access

The Pathogenesis and Advances in Human Herpesvirus Associated Central Nervous System Diseases

Liu Dong1 , Li Zhongjun2 and Zhang Shuai3*

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China 2 Department of Neurosurgery, Beijing Jingmei Group General Hospital, China 3 Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, China

*Correspondance to: Zhang Shuai 

 PDF  Full Text DOI: 10.25107/2474-1647.3054


Human Herpesvirus (HHV) is a large class of double stranded DNA virus that can cause a generalized rash after infection, mainly cause skin and mucous membrane damage, leading to the oral herpes, herpes dermatitis, genital herpes, et al. The virus will be long-standing with the host after infected, latent infection and cyclical recurrence are the pathogenic characteristics of HHV. Intermittent replication is one important reason that the virus cannot be completely eradicated by body immune system. HHV infection can stimulate the body's inherent and acquired immune response, including the inherent immune cells, cytokines and T lymphocytes. The host cells infected the virus can inhibit the replication and proliferation of HHV by inducing apoptosis. In recent decades, with the deepening research and understanding of HHV, the virus is associated with some Central Nervous System diseases (CNS), such as intracranial tumors, encephalitis and neurodegeneration diseases and so on. This paper will review the pathogenesis and advances of the CNS diseases caused by HHV for colleague?s reference


Human herpesvirus; Central nervous system diseases; Pathogenesis

Cite the article

Dong L, Zhongjun L, Shuai Z. The Pathogenesis and Advances in Human Herpesvirus Associated Central Nervous System Diseases. Clin Surg. 2021; 6: 3054..

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