Major Scope

  •  Colon and Rectal Surgery
  •  General Surgery
  •  Gynecologic Oncology
  •  Plastic Surgery
  •  Neurological Surgery
  •  Orthopaedic Surgery
  •  Orthopaedic Surgery of the Spine
  •  Neonatal Surgery
  •  Prenatal Surgery
  •  Trauma Surgery
  •  Surgical Intensivists, Specializing In Critical Care Patients
  •  Thoracic Surgery
  •  Congenital Cardiac Surgery
  •  Thoracic Surgery-Integrated
  •  Vascular Surgery

Abstract

Citation: Clin Surg. 2020;5(1):2952.Research Article | Open Access

Changes in the Expression of Notch and HIF-1? Signaling Molecules in Prostate Cancer Progression

Wei Chen1,3#, Li-Na He2#, Cheng-Wu He4 , Xiang Zeng1 , Guang-Qing Fu1 , Ming-Qiang Su1 , XinYang Fu5 , Jian-hui Liu2 and Yong Liang1*

1 Department of Urology, Zigong Fourth People?s Hospital, Sichuan, China 2 Department of Reproductive Medicine, Zigong Maternity and Child Healthcare Hospital, Sichuan, China 3 Department of Science and Education, Zigong Fourth People?s Hospital, Sichuan, China 4 Department of Urology, The Eighth Affiliated Hospital of Sun Yet-Sen University, Guangdong, China 5 Department of Urology, Kaiping Central Hospital, Guangdong, China # These authors contributed equally to this study

*Correspondance to: Yong Liang 

 PDF  Full Text DOI: 10.25107/2474-1647.2952

Abstract

Objective: To explore the expression and clinical significance of Notch and HIF-1? signaling molecules in the progression of prostate cancer. Method: A total of 68 cases with prostate cancer were enrolled to detecting the expression level of Notch1, HIF-1? and Hes1 mRNA by qRT-PCR, in which the protein expression was measured by western blotting and immunohistochemistry staining, respectively. Correlation between molecules above and clinical pathological parameters were further analyzed. Results: Both Notch signaling and HIF-1? signaling molecules were overexpressed in prostate cancer on the protein level as well as mRNA level when compared to the para-caner tissues (P

Keywords

Prostate cancer; Notch1; HIF-1?; Hes1; Signaling pathway

Cite the article

Chen W, He L-N, He C-W, Zeng X, Fu G-Q, Su M-Q, et al. Changes in the Expression of Notch and HIF-1? Signaling Molecules in Prostate Cancer Progression. Clin Surg. 2020; 5: 2952..

Journal Basic Info

  • Impact Factor: 2.395**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
  • NLM ID: 101702548

Search Our Journal

Journal Indexed In

Articles in PubMed

Antimicrobial Peptides: A Potential Therapeutic Option for Surgical Site Infections
 PubMed  PMC  PDF  Full Text
Risk Factors for Visual Impairment in an Uninsured Population and the Impact of the Affordable Care Act
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Improving the Performance of V-Net Architecture for Volumetric Medical Image Segmentation by Implementing a Gradient Pre-Processor
 Abstract  PDF  Full Text
Systematical Analysis of Circular RNAs in Triple Negative Breast Cancer
 Abstract  PDF  Full Text
View More...