Changes in the Expression of Notch and HIF-1? Signaling Molecules in Prostate Cancer Progression

Wei Chen1,3#, Li-Na He2#, Cheng-Wu He4 , Xiang Zeng1 , Guang-Qing Fu1 , Ming-Qiang Su1 , XinYang Fu5 , Jian-hui Liu2 and Yong Liang1*

1 Department of Urology, Zigong Fourth People?s Hospital, Sichuan, China 2 Department of Reproductive Medicine, Zigong Maternity and Child Healthcare Hospital, Sichuan, China 3 Department of Science and Education, Zigong Fourth People?s Hospital, Sichuan, China 4 Department of Urology, The Eighth Affiliated Hospital of Sun Yet-Sen University, Guangdong, China 5 Department of Urology, Kaiping Central Hospital, Guangdong, China # These authors contributed equally to this study

^*Correspondance to: Yong Liang 

 PDF  Full Text DOI: 10.25107/2474-1647.2952

Abstract

Objective: To explore the expression and clinical significance of Notch and HIF-1? signaling molecules in the progression of prostate cancer. Method: A total of 68 cases with prostate cancer were enrolled to detecting the expression level of Notch1, HIF-1? and Hes1 mRNA by qRT-PCR, in which the protein expression was measured by western blotting and immunohistochemistry staining, respectively. Correlation between molecules above and clinical pathological parameters were further analyzed. Results: Both Notch signaling and HIF-1? signaling molecules were overexpressed in prostate cancer on the protein level as well as mRNA level when compared to the para-caner tissues (P

Keywords

Prostate cancer; Notch1; HIF-1?; Hes1; Signaling pathway

Cite the article

Chen W, He L-N, He C-W, Zeng X, Fu G-Q, Su M-Q, et al. Changes in the Expression of Notch and HIF-1? Signaling Molecules in Prostate Cancer Progression. Clin Surg. 2020; 5: 2952..