Study on Risk Factors and Prognosis of Lymph Node Metastasis of Siewert II/III Adenocarcinoma of Esophagogastric Junction

Tang Huazhen, Zhengzhi, Yinjie, Caijun, Zhang Jun and Zhang Zhongtao

Department of Surgery, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China

^*Correspondance to: Zhang Jun 

 PDF  Full Text DOI: 10.25107/2474-1647.2573

Abstract

Purpose: This study aimed to explore the risk factors and prognosis of lymph node metastasis in patients with Siewert II/III AEG. Methods and Materials: 65 Siewert II/III AEG patients undergoing surgical treatment (open or laparoscopic surgery) from July 2013 to May 2017, with complete clinical data from Beijing Friendship Hospital were included in the study. Patients were followed up until September 2017. Results: Multivariate analysis revealed that histological classification (OR=3.437, 95% CI: 1.046~11.294, P=0.042) and intravascular cancer embolus (OR=6.614, 95% CI: 1.942~22.524, P=0.003) were correlated with lymph node metastasis. Lymph nodes No. 1, 2, 3, 7, 11 and 110 groups showed a high lymph node metastatic rate. The 3-year overall survival analysis revealed that lymph node metastasis (P=0.167) and tumor staging (P=0.429) showed no significant differences. Conclusion: Histological type and vascular neoplasia are risk factors of lymph node metastasis. For Siewert II/III AEG patients, radical total gastrectomy combined with D2 lymphatic nodes dissection was suggested, No. 110 lymph nodes should be also dissected routinely. However, the long-term prognosis remains to be further studied.

Keywords

Adenocarcinoma of esophagogastric junction; Siewert II/III; Logistic regression analysis; Lymphatic metastasis; Survival analysis

Cite the article

Huazhen T, Zhengzhi, Yinjie, Caijun, Jun Z, Zhongtao Z. Study on Risk Factors and Prognosis of Lymph Node Metastasis of Siewert II/III Adenocarcinoma of Esophagogastric Junction. Clin Surg. 2019; 4: 2573..