Optimal Surgical Procedure for Ovarian Metastases from Colorectal Cancer based on a Retrospective Analysis

Wang Song, Dan Huang, Tian’an Guo, Weiqi Sheng, Sanjun Cai,Yuchen Wu, Ye Xu and Fangqi Liu

Department of Oncology, Shanghai Medical College, Fudan University, China
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, China
Department of Pathology, Fudan University Shanghai Cancer Center, China
Both authors contributed equally to this work

^*Correspondance to: Fangqi Liu 

 PDF  Full Text DOI: 10.25107/2474-1647.2475

Abstract

Background and
Objectives: The incidence of ovarian metastases from colorectal cancer (CROM) is 2.1% to 14.2%, and the prognosis is poor. This study aimed to identify optimal surgical procedure for CROM through analysis of the clinicopathological characteristics of such patients and the efficacy of resection for ovarian metastases.
Methods: We retrospectively analyzed the records of 222 patients who were diagnosed with CROM and underwent surgery between June 2006 and December 2015 at the Fudan University Cancer Center, Shanghai, China.
Results: The median Overall Survival (OS) time after ovarian metastasectomy was 30.4 months, and the 5-year OS rate was 29.4%. The 5-year OS rate was significantly higher in patients who underwent R0 resection (41%) vs. R1/2 resection (17%, p=0.001). In patients who had unilateral ovarian metastases and underwent R0 resection, bilateral oophorectomy provided no significantly different OS time in comparison to unilateral oophorectomy (p=0.967). In patients without uterine metastases who underwent R0 resection, there was no significant difference between those who underwent hysterectomy and those who did not (p=0.340).
Conclusion: R0 resection of CROM has better OS rates and times than does R1/2 resection. Young women with unilateral ovarian metastases who want to preserve their ovarian function could undergo unilateral oophorectomy. For R0 resection, hysterectomy is unnecessary when the uterus is not involved.

Keywords

Colorectal cancer; Ovarian metastases; Metastasectomy

Cite the article

Song W, Huang D, Guo T, Sheng W, Cai S,Wu Y, et al. Optimal Surgical Procedure for Ovarian Metastases from Colorectal Cancer based on a Retrospective Analysis. Clin Surg. 2019; 4: 2475.