Hepatic Infusion of Autologous Bone Marrow Promotes Immune Reconstitution in a Patient Suffering from HIV Kaposi′s Sarcoma

Baochi Liu, Mingrong Cheng, Yixuan Liu, Xiaodong Chen, Lei Li, Yanhui Si, Shijia Wang, Ying Wang and Yufang Shi,

Department of Surgery, Shanghai Public Health Clinical Center, Fudan University, China
Department of Life Sciences and Technology, Tongji University, China
Department of Stem Cell Biology, Shanghai Institutes for Biological Sciences, China
Department of Radiation Medicine and Protection, Soochow University, China

^*Correspondance to: Baochi Liu 

 PDF  Full Text DOI: 10.25107/2474-1647.2358

Abstract

Chemotherapy may aggravate the immune damage of AIDS with malignant tumors, but chemotherapy is a necessary treatment. One patient with AIDS complicated with Kaposi’s sarcoma and developed severe immune damage and perianal infection after a course of chemotherapy. Sigmoid colostomy and intravenous catheterization were performed. Before the second chemotherapy, autologous bone marrow was collected for preservation, and day 5 after the end of chemotherapy, the autologous bone marrow was transferred back to the port by buried infusion. The bone marrow was preserved before each chemotherapy and the preserved bone marrow was restored after chemotherapy. After 6 times chemotherapy, CD4+ T cells increased and infection around anus healed. It is suggested that the preservation of autologous bone marrow can promote the immune reconstruction after chemotherapy.

Keywords

Chemotherapy; Autologous bone marrow; Kaposi&39;s sarcoma; Acquired Immune Deficiency Syndrome

Cite the article

Liu B, Cheng M, Liu Y, Chen X, Li L, Si Y, et al. Hepatic Infusion of Autologous Bone Marrow Promotes Immune Reconstitution in a Patient Suffering from HIV Kaposi′s Sarcoma. Clin Surg. 2019; 4: 2358.