Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Vascular Surgery
  •  Endocrine Surgery
  •  Urology
  •  Ophthalmic Surgery
  •  Transplant Surgery
  •  Orthopaedic Surgery
  •  Pediatric Surgery
  •  Thoracic Surgery

Abstract

Citation: Clin Surg. 2019;4(1):2357.Research Article | Open Access

Twenty-year Experience of Post-transplant Lymphoproliferative Disorders in Liver Transplantation, Assessment of Risk Factors, Disease Management and Survival

Media N Ismael, Consuelo Soldevila-Pico and Roniel Cabrera

Department of Internal Medicine Residency, University of Florida, USA
Department of Gastroenterology, University of Florida, USA

*Correspondance to: Roniel Cabrera 

 PDF  Full Text DOI: 10.25107/2474-1647.2357

Abstract

Background: Post-transplant Lymphoproliferative Disorder (PTLD) is a rare complication that occurs post transplantation. Prognosis and mortality are not well established in adult Liver Transplant (LT). In this study we review LT patients who develop PTLD.
Methods: We retrospectively reviewed adult LT PTLD over a twenty-year period at our transplant center. Diagnosis was confirmed by biopsy. Patient characteristics and survival were assessed.
Results: Nineteen patients had PTLD. Majority were Caucasian, age of 50 years with a slight male predominance at LT. Most common indication for LT was primary sclerosing cholangitis. Median time from LT to diagnosis was 6.48 years. Diffuse large B cell lymphoma was the most common form of PTLD, with a minority of only three patients having EBV in tumor pathology. Five patients passed away within a median of 3.7 months from PTLD diagnosis. Overall 5-year survival from PTLD diagnosis was 77.6%.
Conclusion: Low incidence of PTLD in LT with heterogeneous presentations makes early diagnosis difficult. Use of EBV monitoring to aide detection may be insufficient as the sole screening method. A higher suspicion for vague symptoms may be used in patients with PSC disease. These findings highlight need for multicenter collaborations to better understand this condition.

Keywords

Cite the article

Ismael MN, Soldevila-Pico C, Cabrera R. Twenty-year Experience of Posttransplant Lymphoproliferative Disorders in Liver Transplantation, Assessment of Risk Factors, Disease Management and Survival. Clin Surg. 2019; 4: 2357.

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