Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
- Ophthalmic Surgery
- Gastroenterological Surgery
- Robotic Surgery
- Surgical Oncology
- Emergency Surgery
- Obstetrics Surgery
- Cardiovascular Surgery
- Oral and Maxillofacial Surgery
Citation: Clin Surg. 2019;4(1):2357.Research Article | Open Access
Twenty-year Experience of Post-transplant Lymphoproliferative Disorders in Liver Transplantation, Assessment of Risk Factors, Disease Management and Survival
Department of Internal Medicine Residency, University of Florida, USA
Department of Gastroenterology, University of Florida, USA
Background: Post-transplant Lymphoproliferative Disorder (PTLD) is a rare complication that occurs post transplantation. Prognosis and mortality are not well established in adult Liver Transplant (LT). In this study we review LT patients who develop PTLD.
Methods: We retrospectively reviewed adult LT PTLD over a twenty-year period at our transplant center. Diagnosis was confirmed by biopsy. Patient characteristics and survival were assessed.
Results: Nineteen patients had PTLD. Majority were Caucasian, age of 50 years with a slight male predominance at LT. Most common indication for LT was primary sclerosing cholangitis. Median time from LT to diagnosis was 6.48 years. Diffuse large B cell lymphoma was the most common form of PTLD, with a minority of only three patients having EBV in tumor pathology. Five patients passed away within a median of 3.7 months from PTLD diagnosis. Overall 5-year survival from PTLD diagnosis was 77.6%.
Conclusion: Low incidence of PTLD in LT with heterogeneous presentations makes early diagnosis difficult. Use of EBV monitoring to aide detection may be insufficient as the sole screening method. A higher suspicion for vague symptoms may be used in patients with PSC disease. These findings highlight need for multicenter collaborations to better understand this condition.
Cite the article
Ismael MN, Soldevila-Pico C, Cabrera R. Twenty-year Experience of Posttransplant Lymphoproliferative Disorders in Liver Transplantation, Assessment of Risk Factors, Disease Management and Survival. Clin Surg. 2019; 4: 2357.