Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Pediatric Surgery
- Urology
- Obstetrics Surgery
- Endocrine Surgery
- Emergency Surgery
- Gastroenterological Surgery
- Bariatric Surgery
- Gynecological Surgery
Abstract
Citation: Clin Surg. 2019;4(1):2332.Research Article | Open Access
Decreased Lipid Serum Level after Pituitary Adenoma Resection
Jianmei Yang, Miaoqing Zhao, Yejun Qin, Qiang Zhu, Qiangxiu Wang, Kunpeng Wu, Shounan Yi, Haitao Yuan, Lingwei Liu, Ranran Shi, Yashuang Yang, Ying Gong, Ru Feng, Sisi Luan, Yizhou Zou, Wenyu Jia, Zhenyu Yao, Liya Zhang, Xiang Li, Zhao He, Xu Hou, Ling Gao and Jiajun Zhao
Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, China
Shandong Academy of Clinical Medicine, China
Shandong Clinical Medical Center of Endocrinology and Metabolism, China
Department of Pathology, Shandong Provincial Hospital affiliated to Shandong University, China
Department of Medical Service, Shandong Provincial Hospital affiliated to Shandong University, China
University of Sydney at West mead Hospital, Australia
Department of Cardiac Care Unit, Shandong Provincial Hospital affiliated to Shandong University, China
Shandong Provincial Hospital affiliated to Shandong University, China
*Correspondance to: Jiajun Zhao
PDF Full Text DOI: 10.25107/2474-1647.2332
Abstract
Objective: The aim is to evaluate the relationship between pituitary adenoma and serum lipid by pre- and post-operative.Methods: A retrospective analysis based on the clinical records of patients with pituitary adenoma was performed. A total of 1095 patients were diagnosed and underwent surgery through the endoscopic transsphenoidal approach at the Shandong Provincial Hospital (Jinan, China) from July 2010 to June 2015. According to the inclusion criteria, 959 patients were included and analyzed. The fasting lipid profile was obtained in the medical records. Pituitary adenomas are classified as different types according to histological diagnoses. The proportion of serum lipid disorders in various pituitary adenomas was analyzed in pre- and post-operative.Results: Of all patients with PA, approximately 75.7% of patients exhibited dyslipidemia. Each type of tumor was positive association with the serum lipid level (pure Adrenocorticotropic Hormone (ACTH)+ adenomas > pure Follicle-Stimulating Hormone (FSH)/Luteinizing Hormone (LH)+ adenomas > chromophobic adenomas > pure prolactin (PRL)+ adenomas > pure Thyroid- Stimulating Hormone (TSH)+ adenomas > mixed pituitary adenomas > pure Growth Hormone (GH)+ adenomas). Additionally, the serum lipid level decreased after the pituitary adenoma resection. Surprisingly, lipid serum level elevated again when pituitary adenoma recurred and the serum lipid level sharp reduced again follow the second operation. Pituitary adenoma accompanied with dyslipidemia was more easily relapsed. The recurrence ratio of pituitary adenoma in the patients with dyslipidemia was high and up to 2-fold that without lipid disorders, especially TSHoma.Conclusion: There was the relationship between pituitary adenoma and dyslipidemia.
Keywords
Pituitary; Pituitary adenomas; Resection; Recurrence; Serum lipid levels
Cite the article
Yang J, Zhao M, Qin Y, Zhu Q, Wang Q, Wu K, et al. Decreased Lipid Serum Level after Pituitary Adenoma Resection. Clin Surg. 2019; 4: 2332.