Prognostic Factors Affecting Survival and Recurrence in Gastric Carcinoma

Ahmed Itaimi, Oussema Baraket, Wissem Triki, Karim Ayed and Sami Bouchoucha

Department of Medicine, Tunis El Manar University, Tunisia

^*Correspondance to: Ahmed Itaimi 

 PDF  Full Text DOI: 10.25107/2474-1647.2229

Abstract

Background: Gastric adenocarcinoma is a serious and frequent digestive cancer. It is the second leading cause of cancer deaths in the world after colorectal cancer. The bad prognosis is caused by several factors. The identification of prognostic factors will make it possible to better codify therapeutic management in order to improve survival and reduce recurrence rates.Aim: Identify the main prognostic factors affecting overall survival and recurrence in gastric adenocarcinoma.Methods: Retrospective study involving patients undergoing surgery for gastric adenocarcinoma between January 2006 and March 2016 in Habib Bougatfa Hospital in Tunisia.Results: Overall survival was 58% at 3 years. Survival without recurrence was 20 months. Survival without recurrence at 1 year, 3 years and 5 years were respectively 88%, 73% and 70%. Eleven patients had a recurrence. The median time to onset of recurrence was 12 months. Of the 11 patients who had a recurrence, nine had died. Mortality due to recurrence was 82%. In univariate analysis, overall survival and recurrence were influenced by several factors. After multivariate analysis, lymph node invasion, occurrence of recurrence, number of lymph nodes removed less than 15, presence of signet-ring cell carcinoma and tumor stage 3 and 4 significantly influenced survival. Independent factors influenced recurrences were: the presence of lymph nodes and signet ring cell carcinoma.Conclusion: Several factors influence overall survival and recurrence in gastric adenocarcinoma. The lymph node invasion and the anatomo-pathological factors are the most important. Improving therapeutic outcomes requires early diagnosis and careful surgery.

Keywords

Gastric Cancer; Prognosis; LBVI

Cite the article

Itaimi A, Baraket O, Triki W, Ayed K, Bouchoucha S. Prognostic Factors Affecting Survival and Recurrence in Gastric Carcinoma. Clin Surg. 2018; 3: 2229.