Morphological Placental Portraits in Congenital Diaphragmatic Defects: A Pathological Study Approach

Rosete Nogueira, Pedro Cardoso, Ana Cristina Braga, Cláudia Almeida, Cristina Nogueira- Silva, Jorge Correia Pinto

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Surgical Sciences Domain, Campus de Gualtar; 4710-057, Braga, Portugal
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
CGC Genetics, Embryofetal Pathology Laboratory, 706, 1º, 4000-432, Porto, Portugal
School of Engineering, University of Minho, Department of Production and Systems, Braga, Portugal

^*Correspondance to: Rosete Nogueira 

 PDF  Full Text DOI: 10.25107/2474-1647.2197

Abstract

Introduction: The pathogenesis of Congenital Diaphragmatic Defects (CDD) is not clear. Placental factors have been implicated in the pathogenesis of congenital anomalies.Objective: To assess the placental measurements on CDD and to compare with a group of fetuses without CDD. Material and
Methods: In this retrospective cross-study, 30 placentas of fetuses with CDD sent to Embryo fetal Pathology Laboratory, Centro de Genética Clínica (CGC), Porto, was evaluated. To compare the placental parameters in CDD group, 71 placentas from fetuses without CDD, matched by Gestational Age (GA) were selected.Conclusion: Placental size and umbilical cord length and diameter have an impact on CDD.

Keywords

Congenital diaphragmatic defects; Diaphragmatic agenesis; Diaphragmatic eventration; Placenta size; Umbilical cord length; Umbilical cord diameter

Cite the article

Nogueira R, Cardoso P, Braga AC, Almeida C, Nogueira-Silva C, Pinto JC. Morphological Placental Portraits in Congenital Diaphragmatic Defects: A Pathological Study Approach. Clin Surg. 2018; 3: 2197.