Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy: A Prospective Randomized Study

Mohammed A. Omar and Marwa N. Hamed

Department of General Surgery, South Valley University, Qena, Egypt
Department of Anesthesia, Intensive Care and Pain Therapy, South Valley University, Qena, Egypt

^*Correspondance to: Mohammed Ahmed Omar 

 PDF  Full Text DOI: 10.25107/2474-1647.2151

Abstract

Background: Cholecystectomy can prevent recurrent attacks of mild Acute Biliary Pancreatitis (ABP). However, the optimal timing of cholecystectomy remains controversial. The aim of this prospective randomized study is to compare the outcomes of Early Laparoscopic Cholecystectomy (ELC) vs. Delayed Laparoscopic Cholecystectomy (DLC) for patients with mild ABP.Methods: From June 2014 to December 2017, 131 patients with mild ABP were prospectively randomized to either an ELC group (70 patients) or control DLC group (61 patients). The primary outcomes were gallstone-related morbidity and mortality while the secondary outcomes were success and failure rate, the difficulty of cholecystectomy, operative time, cholecystectomy related complications, readmission for gallstone-related complications, hospital stay, ICU admission and additional procedure. The study was registered in the ClinicalTrials.gov PRS register with identification number NCT03085407.Results: There were statistically significant differences in the incidence and number of readmission for gallstone-related complications (5.7% vs. 62.35, P<0.001 & 4.3% vs. 21.3%, P<0.001), and the total length of hospital stay (4.4 ± 1 vs. 6.9 ± 2.6, p=0.03). There were no statistically significant differences in the other parameters of evaluation between both groups.
Conclusion: In mild ABP, ELC can be done safely and efficaciously with a significant reduction in the recurrent biliary events, the total length of hospital stay and frequency of readmission compared with DLC.

Keywords

Acute biliary pancreatitis; Cholecystectomy; Optimal time

Cite the article

Omar MA, Marwa N. Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy: A Prospective Randomized Study. Clin Surg. 2018; 3: 2151.