Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Ophthalmic Surgery
  •  Bariatric Surgery
  •  Urology
  •  Pediatric Surgery
  •  Emergency Surgery
  •  Transplant Surgery
  •  Orthopaedic Surgery
  •  Gynecological Surgery

Abstract

Citation: Clin Surg. 2018;3(1):2002.Research Article | Open Access

The Mechanism of Bacterial Translocation after Major Hepatectomy in Cirrhotic Rats

Jian Liang1,, Zhi-qiang Ye, Shu-xian Chen, Chu-si Wan and Wei-dong Pan

Department of Hepatopancreatobiliary Surgery, The Third Affiliated Hospital of Sun Yat-sen University, China
Department of General Surgery, Hospital of Traditional Chinese Medicine of Zhongshan, China
Department of Emergency, The Third Affiliated Hospital of Sun Yat-sen University, China

*Correspondance to: Wei-dong Pan 

 PDF  Full Text DOI: 10.25107/2474-1647.2002

Abstract

This study was designed to investigate the mechanism underlying bacterial translocation after major hepatectomy in cirrhotic rats. Sixty experimental cirrhotic rats were randomly divided into SO, PH and PHP groups. Portal pressure, the composition of the intestinal micro flora, the levels of D-lactic acid, endo toxins, inflammatory factors, and tight junction proteins were analyzed in the three groups of animal. Portal pressure of the PH rats was significantly higher (22.48 ± 0.882 cm H2O) than that of the SO (14.3 ± 1.25 cm H2O) and PHP rats (16.6 ± 1.02 cm H2O) (P<0.05). The PH rats also showed significantly higher levels of serum LPS and D-lactic acid (52.56 ± 2.08 EU/ml and 60.87 ± 4.44 mg/L) than the SO (48.28 ± 1.45 EU/ml and 37.23 ± 1.71 mg/L) and PHP rats (47.84 ± 3.45 EU/ml and 40.83 ± 1.82 mg/L) (P<0.05). ZO-1 and Claudin-1 levels were significantly higher in the SO and PHP rats than in the PH rats (P<0.05), and the expression levels of TNF-α, IFN-γ, and MLCK were significantly lower in the SO and PHP rats than in the PH rats (P<0.05). Portal pressure significantly increased after major hepatectomy in cirrhotic rats, leading to intestinal stagnant anoxia, the accumulation of local metabolic products and inflammatory factors, the induction of intestinal epithelial cell apoptosis, and changes in the composition of the gut flora. These effects collectively resulted in tight junction functional disorders.

Keywords

Cirrhosis; Major hepatectomy; Bacterial translocation; Gut barrier

Cite the article

Liang J, Ye Z-q, Chen S-x, Wan C-s, Pan W-d. The Mechanism of Bacterial Translocation after Major Hepatectomy in Cirrhotic Rats. Clin Surg. 2018; 3: 2002.

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