Characteristics of Primary Hyperparathyroidism Patients Based on One Saudi Center Experience

Amal Abdulhaq, Saif Alsobhi and Amal Alhefdhi

Department of Surgery, King Faisal Specialist Hospital and Research Center, Saudi Arabia

^*Correspondance to: Amal Alhefdhi 

 PDF  Full Text DOI: 10.25107/2474-1647.1992

Abstract

Introduction: The prevalence and presentation of the Primary Hyperparathyroidism (PHPT) geographically varies. There is a paucity of published literature on PHPT in Saudi Arabia, so this study aimed to investigate the characteristic features and the surgical outcome of PHPT patients.Methods: A retrospective review of PHPT patients underwent parathyroidectomy at King Faisal Specialist Hospital and Research Center, from 2010 to 2016.Results: There were 88 patients; 72 (81.8%) were female and 16 (18.2%) were male. The mean age was 46 ± 15 year. The mean preoperative serum level was 2.85 ± 0.33 for calcium and 407 ± 475 for parathyroid hormone. The majority of the cases presented with bone symptoms 50 patients (56.8%), followed by no symptoms in 25 patients (28.4%), fatigability 7 (7.9%), renal symptoms 4 (4.6%) and gastric symptoms 2 (2.3%). Sestamibi scanning localized diseased gland in 71 cases (81.6%). The causes of PHPT were single adenoma in 75 (85.2%), double adenoma in 6(6.8%) and hyperplasia in 7(8%). The persistent rate was 1.1% and the recurrent rate was 2.2%. Females found to have a lower preoperative vitamin D level comparing with males 39.7 nmol/L ± 28.6 nmol/L vs. 73.87 nmol/L ± 19.73 nmol/L (p= 0.0001). Moreover, patients with multiple gland disease had a higher rate of recurrence comparing with patients with single adenoma 0% vs. 15.4% (p=0.020).Conclusion: While half of PHPT patients in Saudi Arabia still present with bone symptoms, one fourth of the cases are asymptomatic. Moreover, one third of the cases are younger than 40 years old.

Keywords

Primary hyperparathyroidism; Causes; Parathyroidectomy

Cite the article

Abdulhaq A, Alsobhi S, Alhefdhi A. Characteristics of Primary Hyperparathyroidism Patients Based on One Saudi Center Experience. Clin Surg. 2018; 3: 1992.