The Effect of Postoperative Ischemia on Steroid Receptors and C-Erbb-2 Levels in Breast Cancer Tissue

Mehmet Saydam and Ibrahim Yilmaz

Department of General Surgery, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara/Turkey

^*Correspondance to: Mehmet Saydam 

 PDF  Full Text DOI: 10.25107/2474-1647.1677

Abstract

Background: Postoperative ischemia could affect the evaluation of steroid receptors and c-erbB-2 levels in breast cancer tissue until being fixed by formalin. Misevaluation of steroid hormone receptors and c-erbB-2 levels that have high prognostic factor for the treatment of breast cancer may change the treatment options. The aim of this study is to investigate the postoperative ischemia effects to the breast cancer specimen, especially on steroid receptors and c-erbB-2 expression.Methods: Twenty patients who underwent modified radical mastectomy were included in this study. Two histopatholigical methods which are frozen and regular follow-up methods were performed postoperatively to all of the specimens. Steroid receptors; Estorogen Receptors (ERs), Progesterone Receptors (PRs), and c-erbB-2 expression of breast tissue samples were evaluated in both techniques. Two groups were created based on two histopatological technique results of steroid receptors and c-erbB-2.Results: We determined that ischemia has a negative effect on the evaluation of steroid receptors and c-erbB-2 and especially the alteration at c-erbB-2 expression was statistically significant (p<0.002).Conclusion: Mastectomy specimen should be examined in the shortest ischemia time in order to determine the accurate detection of steroid receptors and c-erbB-2 levels.

Keywords

Breast cancer; C-erbB-2; Estrogen receptors; Ischemia, Progesterone receptors

Cite the article

Saydam M, Yilmaz I. The Effect of Postoperative Ischemia on Steroid Receptors and C-Erbb-2 Levels in Breast Cancer Tissue. Clin Surg. 2017; 2: 1677.