Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Obstetrics Surgery
  •  Otolaryngology - Head and Neck Surgery
  •  Gastroenterological Surgery
  •  Urology
  •  Plastic Surgery
  •  Robotic Surgery
  •  Bariatric Surgery
  •  Ophthalmic Surgery


Citation: Clin Surg. 2017;2(1):1509.Case Report | Open Access

Rat Cardiopulmonary Bypass Models to Investigate Multi-Organ Injury

Shingo Hirao, Hidetoshi Masumoto and Kenji Minatoya

Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

*Correspondance to: Hidetoshi Masumoto 

 PDF  Full Text DOI: 10.25107/2474-1647.1509


Cardiopulmonary bypass (CPB) has been an essential modality in cardiovascular surgery. Although the technique has since undergone dramatic refinement, prolonged CPB-related multi-organ complications due to contact activation, ischemia–reperfusion injury, coagulation, endotoxemia and/or production of oxygen free radicals still compromise the outcome of cardiovascular surgeries. Animal models recapitulating the clinical usage of CPB help elucidate the pathophysiological processes following CPB, and aid in the development of strategies aimed at preventing these complications. Rat CPB models mimicking clinical situations in cardiovascular surgery have been refined and have gradually taken the place of large-animal models because of greater costeffectiveness, convenient experimental processes, abundant testing methods at the genetic or protein levels, and genetic consistency. In the present review, we discuss various beneficial aspects of rat CPB models for investigating CPB-related multi-organ injury and for mitigating the severity of complications in an organ-specific manner (lung/kidney/brain/liver/myocardium/intestine). The interventions established through basic research using rat CPB models may further improve the safety of cardiovascular surgery in the future.


Rat cardiopulmonary bypass; Multi-organ injury; Kidney

Cite the article

Hirao S, Masumoto H, Minatoya K. Rat Cardiopulmonary Bypass Models to Investigate Multi-Organ Injury. Clin Surg. 2017; 2: 1509.

Search Our Journal

Journal Indexed In

Articles in PubMed

Mesh Sprayer Device with Liquefied Mesh Delivery System: Proposed Alternative for Currently Available Meshes in Hernia Repair and Supplement to Abdominal Closure
 PubMed  PMC  PDF  Full Text
Voice Outcomes in Laryngotracheal Stenosis: Impact of the Montgomery T-tube
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Acute Appendicitis in Patients with Leukemia: A Dilemma in Diagnosis and Surgical Treatment
 Abstract  PDF  Full Text
Use of the Intrathoracic Tube for Repositioning Free Flap Pedicle via Transoral Approach
 Abstract  PDF  Full Text
View More...