Intervertebral Disk Mediated Postoperative Epidural Fibrosis: Experimental Model and Methods of Prevention

Sergey N. Larionov, Vladimir A. Sorokovikov, Konstantin C. Erdyneyev, Svetlana A. Lepekhova, Oleg A. Goldberg and Anna V. Rudakova

Irkutsk Scientific Center of Surgery and Traumatology, Russia
Department of Traumatology, Orthopedics and Neurosurgery, Irkutsk State Medical Academy of Continuous Education, Russia

^*Correspondance to: Sergey N. Larionov 

 PDF  Full Text DOI: 10.25107/2474-1647.1484

Abstract

The etiology and pathogenesis creates a lot of discussion, and selection of methods of treatment and prevention continues. In this study we used 36 male Wistar rats, each weighing 250 ± 30 g; LIV laminectomy with dura mater exposition was done in 12 rats, and then, 0.3 cc of elements of suspension of autologous intervertebral disk were implicated on dura mater. In 12 animals laminectomy was followed by application of a 5 × 6 mm sheet of Reperen™ on the exposed dura™. Histological assessment of the lumbar spine of rats observed that the elements of autologous intervertebral disk play the role of inflammation trigger, which cause postoperative scar and epidural fibrosis. In another part of the experimental study we revealed that Reperen™ to prevent excessive epidural fibrosis. So, the experimental model and methods of prevention postoperative epidural fibrosis can be widely used in experimental medicine for research of epidural scar-adhesion pathogenesis and for searching the ways of treatment and prevention of the disease in human.

Keywords

Experimental model; Postoperative epidural fibrosis; Laminectomy; Intervertebral disk

Cite the article

Larionov SN, Sorokovikov VA, Erdyneyev KC, Lepekhova SA, Goldberg OA, Rudakova AV. Intervertebral Disk Mediated Postoperative Epidural Fibrosis: Experimental Model and Methods of Prevention. Clin Surg. 2017; 2: 1484.